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TNF-α (72-82), human

TNF-α (72-82), human is a synthetic, 11-amino acid peptide corresponding to residues 72-82 of the mature human Tumor Necrosis Factor-alpha (TNF-α) protein. This research-grade peptide represents a specific linear epitope or functional region within the cytokine. It serves as a specialized tool for immunology and antibody research, particularly for mapping antibody binding sites, studying TNF-α structure-function relationships, and developing specific immunoassays.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	TNF-α (72-82), human
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₁H₉₆N₁₈O₁₅S
Molecular Weight	1365.59 g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, 0.1% TFA, or DMSO; reconstitute to 1–10 mg/mL
Endotoxin	≤1.0 EU/mg
Biological Activity	Lyophilized powder: -20°C to -80°C for long-term storage; avoid repeated freeze-thaw cycles.
Storage Conditions	Temperature-controlled (-20°C) freezer at manufacturer/distributor warehouse
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide itself does not possess the native trimeric structure or full biological activity of the intact TNF-α cytokine. Its mechanism is primarily antigenic. The sequence represents a portion of the solvent-exposed surface of the native TNF-α protein. As a linear epitope, it can be specifically recognized and bound by monoclonal or polyclonal antibodies raised against human TNF-α. It may also interact with certain TNF receptors or neutralizing agents, providing insights into critical binding interfaces. The peptide's utility lies in probing interactions and blocking specific regions without triggering full receptor activation.

2.PRODUCT INDICATIONS

This product is indicated for specialized applications in immunology and biotechnology development. Key uses include: mapping the epitope specificity of anti-TNF-α monoclonal antibodies in antibody characterization and hybridoma screening; serving as a coating antigen or competitor in enzyme-linked immunosorbent assays (ELISAs) to detect TNF-α or anti-TNF antibodies; studying structure-activity relationships by targeting specific regions of the TNF-α molecule; and as an immunogen for generating antibodies against this specific region of TNF-α.

3.CLINICAL EFFICACY OF PRODUCT

TNF-α (72-82), human is a research and diagnostic development tool, not a therapeutic. Its clinical relevance and efficacy are indirect but crucial. It is used extensively in the pharmaceutical industry for the quality control and characterization of biologic drugs. Specifically, it is vital for: 1) Biosimilar Development: Confirming that a biosimilar antibody binds to the same epitope as the reference anti-TNF drug (e.g., adalimumab, infliximab). 2) Antibody Drug Characterization: Defining the precise binding site of therapeutic anti-TNF antibodies, which is a critical quality attribute. 3) Diagnostic Development: Helping to create specific assays to monitor drug levels or anti-drug antibodies in patients undergoing anti-TNF therapy.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.