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Tetrapeptide-16

Tetrapeptide-16 is a synthetic peptide cosmetic ingredient designed for topical formulations targeting skin barrier reinforcement and hydration enhancement. Supplied as a high-purity lyophilized powder, it is engineered for stability and epidermal penetration to support dermal-epidermal junction integrity and improve skin resilience, making it suitable for inclusion in moisturizers, barrier creams, and products for sensitive, dehydrated, or compromised skin conditions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Tetrapeptide-16
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₃H₃₉N₇O₉
Molecular Weight	581.6g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Tetrapeptide‑16 is a synthetic peptide used in cosmetic formulations for its reported ability to enhance skin barrier function, improve hydration, and support dermal‑epidermal junction integrity. It is often incorporated into products targeting sensitive or weakened skin.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Tetrapeptide-16 penetrates the epidermis and acts on keratinocytes to upregulate the expression of key barrier proteins such as filaggrin and involucrin, strengthening the stratum corneum and reducing transepidermal water loss. It also modulates inflammatory signaling pathways associated with skin sensitivity, helping to calm irritation and restore a healthy skin barrier by enhancing intercellular cohesion and lipid organization within the epidermal layers.

2.PRODUCT INDICATIONS

This peptide is indicated for research and development of topical cosmetic and dermocosmetic formulations aimed at improving skin barrier function, hydration, and resilience in sensitive, dehydrated, or environmentally stressed skin. It is used in products such as daily moisturizers, barrier repair creams, and post-procedure formulations, as well as in in vitro and ex vivo models to evaluate barrier integrity, hydration, and soothing effects on compromised skin.

3.CLINICAL EFFICACY OF PRODUCT

Clinical evaluations of formulations containing Tetrapeptide-16 demonstrate significant improvements in skin hydration, reduction in transepidermal water loss, and enhanced barrier function after 4 to 8 weeks of topical application, with subjective improvements in skin comfort and reduction in sensitivity reported in subjects with dry and reactive skin. While these results are supportive, data are primarily from manufacturer-sponsored studies and small-scale trials, and the ingredient is often used in combination with other hydrating and barrier-supporting actives, positioning it as a cosmetic ingredient with evidence for barrier-strengthening and hydrating benefits.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.