Octapeptide-2 CAS NO.1374396-34-5

Octapeptide-2 is a synthetic octapeptide cosmetic ingredient designed for sensitive and reactive skin care formulations, supplied as a high-purity white to off-white lyophilized powder for topical application. It targets the reduction of skin redness, irritation, and barrier compromise by modulating inflammatory pathways and reinforcing the skin's natural defense mechanisms, making it an ideal active for calming and soothing treatments.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Octapeptide-2
CAS NO.	1374396-34-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C38H60N10O16S
Molecular Weight	945.01g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Octapeptide‑2 is a synthetic peptide used in cosmetic formulations for its reported anti‑inflammatory, skin‑soothing, and barrier‑supporting properties. It is designed to help calm sensitive, irritated skin and strengthen the skin barrier.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts by inhibiting the release of pro-inflammatory cytokines such as IL-1α, IL-6, and TNF-α from keratinocytes and immune cells, thereby reducing the inflammatory cascade that leads to redness and sensitivity. It also enhances the expression of key barrier proteins like filaggrin and involucrin, strengthening the stratum corneum and improving skin barrier function to prevent transepidermal water loss and external irritant penetration.

2.PRODUCT INDICATIONS

Octapeptide-2 is indicated for research and development of topical cosmetic formulations targeting sensitive, reactive, and redness-prone skin, including calming serums, post-procedure treatments, and barrier repair creams. It is suitable for products aimed at rosacea-prone skin, post-inflammatory erythema, and environmentally stressed skin, as well as for in vitro models evaluating anti-inflammatory and barrier enhancement efficacy.

3.CLINICAL EFFICACY OF PRODUCT

Clinical evaluations of formulations containing Octapeptide-2 demonstrate a significant reduction in skin redness, irritation, and subjective discomfort after 4–8 weeks of topical use, with instrumental measurements confirming improved barrier function and reduced transepidermal water loss. Subjective assessments report enhanced skin comfort and resilience, positioning it as an efficacious cosmetic ingredient for sensitive skin and anti-redness formulations, supported by controlled studies.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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