Coffeoyl Tripeptide -1

Coffeoyl Tripeptide-1 is a synthetic, innovative peptide conjugate that combines a tripeptide sequence with a caffeic acid (coffeoyl) derivative. This unique structure merges the benefits of bioactive peptides and potent plant-based antioxidants. It is engineered for advanced cosmetic applications, primarily focused on powerful antioxidant protection, anti-inflammatory action, and the prevention of oxidative stress-induced skin aging. It helps defend skin against environmental damage and supports a healthier, more resilient complexion.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Caffeoyl Tripeptide-1
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₀H₂₃N₃O₈
Molecular Weight	433.41 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥10 mg/ml), ethanol, and DMSO
Endotoxin	≤50 EU/mg
Biological Activity	Potent antioxidant that neutralizes free radicals, protects skin from oxidative stress; skin-protecting agent that supports barrier function and may reduce photoaging signs; exhibits mild anti-inflammatory effects
Storage Conditions	Store at -20°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Coffeoyl Tripeptide-1 functions through a synergistic dual-action mechanism, leveraging both its peptide and caffeic acid components:

Potent Antioxidant Activity: The caffeic acid (coffeoyl) moiety is a powerful phenolic antioxidant. It directly scavenges a wide range of free radicals (ROS, RNS) generated by UV radiation, pollution, and other environmental stressors. It also possesses metal-chelating properties, preventing Fenton reactions that produce highly damaging hydroxyl radicals.
Cell Signaling & Protection: The tripeptide sequence is designed to provide cellular communication benefits. It may help upregulate the skin's own endogenous antioxidant defense systems (e.g., via Nrf2 pathway activation) and promote protective cellular responses.
Anti-inflammatory Effects: Both components contribute to reducing inflammation. Caffeic acid is known to inhibit pro-inflammatory enzymes like COX-2 and cytokines, while the peptide may further modulate inflammatory signaling pathways in skin cells.

2.PRODUCT INDICATIONS

This product is indicated for cosmetic science and the formulation of high-performance protective and reparative skincare. Key applications include:

As a premier active in antioxidant serums, day creams, and ampoules for environmental defense against pollution, blue light, and UV-induced oxidative stress.
In anti-aging regimens to prevent and repair signs of photoaging, such as wrinkles, loss of elasticity, and uneven tone.
For soothing and calming formulations targeting sensitive or inflamed skin conditions.
In post-procedure skincare to support healing and protect newly treated skin.
As a key ingredient in broad-spectrum protective products that go beyond sunscreens to neutralize free radicals.

3.CLINICAL EFFICACY OF PRODUCT

Coffeoyl Tripeptide-1 is supported by robust in vitro data on its radical scavenging capacity (e.g., ORAC value) and anti-inflammatory activity. Clinical studies on cosmetic formulations containing this ingredient demonstrate:

Significant Reduction in Oxidative Stress Markers: Measurable decrease in markers of skin oxidation following exposure to environmental stressors.
Visible Improvement in Signs of Photoaging: Reduction in the appearance of fine lines, wrinkles, and improvements in skin elasticity and firmness with regular use.
Enhanced Skin Brightness and Even Tone: Helps combat dullness and hyperpigmentation caused by oxidative stress.
Calming Effect on Skin: Reduces redness and sensitivity, improving overall skin comfort.
Potentiation of Sunscreen Efficacy: When used with sunscreen, it provides a complementary layer of protection by neutralizing free radicals that penetrate physical/chemical filters.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.