Grb2 SH2 Domain Ligand CAS NO.168423-05-0
Grb2 SH2 Domain Ligand CAS NO.168423-05-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Grb2 SH2 Domain Ligand |
| CAS NO. | 168423-05-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C23H361N5O10P |
| Molecular Weight | 573.56g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water or suitable buffer to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This product is a peptide or small‑molecule ligand designed to bind with high affinity and selectivity to the SH2 domain of the adaptor protein Grb2. It is used in biochemical and cellular assays to study Grb2‑mediated signaling pathways, such as Ras/MAPK activation, receptor tyrosine kinase signaling, and cell proliferation. Activity is validated by SH2 domain binding assays (e.g., SPR, ITC, competitive ELISA). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The ligand exerts its function by competitively binding to the phosphotyrosine-binding pocket of the Grb2 SH2 domain, disrupting the recruitment of Grb2 to activated receptor tyrosine kinases (RTKs) or scaffold proteins. This blockade prevents the formation of the Grb2-SOS complex, thereby inhibiting downstream Ras GTP loading, MAPK/ERK pathway activation, and subsequent transcriptional events driving cell growth, differentiation, and survival, without directly affecting kinase catalytic activity.
2.PRODUCT INDICATIONS
Grb2 SH2 Domain Ligand is indicated for research use in studying RTK signaling, oncogenic transformation, and immune cell activation in vitro and in cell-based assays. It is suitable for applications including competitive binding studies (SPR, ITC, ELISA), cellular pathway inhibition experiments, high-throughput screening for Grb2 inhibitors, and mechanistic validation of Grb2-dependent phenotypes in cancer, developmental biology, and immunology research contexts.
3.CLINICAL EFFICACY OF PRODUCT
As a research tool compound, Grb2 SH2 Domain Ligand is not intended for clinical use and has no established human efficacy data. Preclinical studies demonstrate its ability to potently inhibit Grb2-dependent signaling in cancer cell lines, reducing ERK phosphorylation, cell proliferation, and migration in a dose-dependent manner, supporting its utility as a pharmacological probe to validate Grb2 as a therapeutic target and to characterize next-generation inhibitors in drug discovery pipelines.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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