[Asn370] tyrosinase (368–376)

[Asn370] Tyrosinase(368-376), human is a synthetic nine-amino acid peptide representing residues 368-376 of the human tyrosinase enzyme, with a specific asparagine substitution at position 370. This modified epitope is designed for immunological research, particularly in the study of T-cell responses against melanocyte antigens, making it a critical tool for investigating melanoma immunology, autoimmune vitiligo, and the development of antigen-specific cancer vaccines.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Asn370] tyrosinase (368–376)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C42H67N11O15S2
Molecular Weight	1030.19 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide is a modified epitope derived from human tyrosinase, often used in immunological research (e.g., T‑cell activation studies, epitope mapping, vaccine development) related to melanoma and autoimmune vitiligo. The Asn³⁷⁰ substitution may alter MHC‑binding affinity and T‑cell recognition.
Storage Conditions	Available from specialized peptide and immunological reagent suppliers (e.g., GenScript, Peptide 2.0, ApexBio) with warehouses in North America, Europe, and Asia.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a defined T-cell epitope. When processed and presented by antigen-presenting cells via MHC class I molecules, it engages with specific T-cell receptors on CD8+ cytotoxic T lymphocytes. This interaction triggers T-cell activation, proliferation, and the release of cytotoxic molecules and cytokines, initiating an adaptive immune response targeted against cells expressing the native tyrosinase antigen, a key process in anti-melanoma immunity and vitiligo pathogenesis.

2.PRODUCT INDICATIONS

The peptide is indicated for research applications in cancer immunology and autoimmunity, including in vitro T-cell activation and proliferation assays, epitope mapping, immune monitoring of melanoma patients, and preclinical evaluation of tyrosinase-targeted immunotherapies such as peptide vaccines and adoptive T-cell transfer. It is also used in studies exploring the mechanisms of immune tolerance and breakdown in autoimmune vitiligo.

3.CLINICAL EFFICACY OF PRODUCT

[Asn370] Tyrosinase(368-376) is a research-grade reagent and is not an approved therapeutic. However, tyrosinase-derived epitopes are central to numerous clinical-stage melanoma vaccine trials. Early-phase clinical studies have demonstrated that immunization with such peptides can induce tyrosinase-specific T-cell responses, and in some cases, correlate with clinical benefit, supporting the continued investigation of this epitope in cancer immunotherapy, though its standalone efficacy requires further validation in larger controlled trials.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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