Hepcidin-1 (mouse) trifluoroacetate salt CAS NO.1676104-75-8

Hepcidin-1 (mouse) trifluoroacetate salt is a synthetic peptide hormone that plays a central role in systemic iron regulation. This mouse-specific analog is provided in a high-purity, soluble trifluoroacetate salt form, making it an essential research tool for investigating iron homeostasis, anemia, and inflammation-related hypoferremia in preclinical murine models, with its structure featuring conserved disulfide bonds critical for biological activity.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Hepcidin-1 (mouse) trifluoroacetate salt
CAS NO.	1676104-75-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C111H169N31O35S8
Molecular Weight	2754.28g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Mouse Hepcidin‑1 is a key iron‑regulatory hormone produced by the liver. It binds to ferroportin, inducing its internalization and degradation, thereby inhibiting iron efflux from macrophages, hepatocytes, and intestinal cells. This product is commonly used in studies of iron metabolism, anemia, and inflammatory hypoferremia. Bioactivity can be validated in ferroportin‑internalization assays or iron‑secretion inhibition assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as the master regulator of iron homeostasis by binding to the cellular iron exporter ferroportin on the surface of macrophages, hepatocytes, and enterocytes. This binding triggers the internalization and degradation of ferroportin, thereby inhibiting cellular iron export, sequestering iron within cells, and reducing serum iron levels, which is a key response to inflammation and iron overload.

2.PRODUCT INDICATIONS

This product is indicated for research use in studying iron metabolism disorders, including hereditary hemochromatosis, anemia of inflammation, and iron-refractory iron deficiency anemia in mouse models. It is employed in in vitro assays to measure ferroportin internalization, in vivo studies to induce hypoferremia, and preclinical investigations of hepcidin agonists or antagonists for therapeutic development.

3.CLINICAL EFFICACY OF PRODUCT

Hepcidin-1 (mouse) trifluoroacetate salt is a research-grade reagent and is not approved for clinical use in humans. However, studies using this mouse-specific peptide have been instrumental in validating hepcidin as a therapeutic target, informing the development of human hepcidin mimetics and ferroportin inhibitors currently in clinical trials for iron overload disorders and certain anemias.

4.DELIVERY & SHIPPING

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