Angiotensin CAS NO.58-49-1
Angiotensin CAS NO.58-49-1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Angiotensin II, human |
| CAS NO. | 58-49-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₅₀H₇₁N₁₃O₁₂ |
| Molecular Weight | 1046.18g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥5 mg/mL); soluble in 0.1 M acetic acid; soluble in DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent vasoconstrictor; raises blood pressure; stimulates aldosterone secretion; acts as an agonist for angiotensin receptors (AT1 and AT2). Widely used in cardiovascular, hypertension, and renal research. |
| Storage Conditions | Store at -20°C; long-term at -80°C; protect from light and moisture; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Angiotensin I itself has minimal direct biological activity at the AT1 receptor. Its primary role is as a precursor molecule in a tightly regulated enzymatic cascade:
- Formation: It is produced in the bloodstream by the action of renin on its substrate, angiotensinogen (synthesized in the liver).
- Conversion to Angiotensin II: The key step in the RAS is the cleavage of the C-terminal dipeptide (His-Leu) from Angiotensin I by the membrane-bound angiotensin-converting enzyme (ACE), primarily in the lungs. This reaction generates the octapeptide Angiotensin II, the primary active effector of the system.
- Biological Activity via Angiotensin II: Angiotensin II exerts powerful effects by binding to AT1 and AT2 receptors, leading to:
- Vasoconstriction of arterioles, increasing peripheral resistance and blood pressure.
- Stimulation of aldosterone secretion from the adrenal cortex, promoting sodium and water retention.
2.PRODUCT INDICATIONS
This product is indicated for a wide range of research in cardiovascular physiology, pharmacology, and biochemistry. Key applications include:
- Angiotensin-Converting Enzyme (ACE) Activity Assays: As the definitive, natural substrate for in vitro and ex vivo measurement of ACE activity. It is used to screen and characterize ACE inhibitors (e.g., captopril, lisinopril), which are first-line therapies for hypertension and heart failure.
- Renin-Angiotensin System (RAS) Research: Studying the biochemistry, regulation, and tissue-specific expression of the entire RAS pathway.
- Hypertension & Cardiovascular Disease Models: Used to investigate the role of the RAS in animal models of hypertension, heart failure, and kidney disease.
- Enzyme Kinetics & Characterization: A standard substrate for determining kinetic parameters (Km, Vmax) of ACE and studying enzyme inhibition mechanisms.
- Drug Discovery & Development: A critical component in high-throughput screening platforms for identifying novel antihypertensive agents that target the RAS.
3.CLINICAL EFFICACY OF PRODUCT
Angiotensin I itself is not a clinical therapeutic. Its immense importance lies in its pivotal role as the target of one of the most successful drug classes in history.
- Foundation for ACE Inhibitor Therapy: The very definition of ACE activity is its ability to convert Angiotensin I to Angiotensin II. Therefore, Angiotensin I is the essential substrate used to:
- Discover and develop all ACE inhibitor drugs.
- Standardize clinical laboratory tests for measuring plasma ACE activity (e.g., for sarcoidosis diagnosis).
- Monitor the pharmacodynamic effect of ACE inhibitor therapy in patients.
- Cornerstone of Hypertension Understanding: Research using this peptide has been fundamental to elucidating the pathophysiology of hypertension, congestive heart failure, and diabetic nephropathy—all conditions where ACE inhibitors are now cornerstone therapies.
- Diagnostic Utility: Measurement of plasma Angiotensin I, in conjunction with renin activity, is used in the diagnostic workup of certain forms of hypertension (e.g., renovascular hypertension).
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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