Antioxidant peptide A CAS NO.159147-88-3

Antioxidant Peptide A (CAS NO. 159147-88-3) is a specific synthetic peptide sequence derived from natural protein hydrolysates, known for its potent free radical scavenging and metal-chelating activities. This high-purity, research-grade peptide is designed to protect cells and biological systems from oxidative stress damage caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS). It is used in antioxidant research, nutraceutical studies, and the development of protective cosmetic and pharmaceutical formulations.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Antioxidant peptide A
CAS NO.	159147-88-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C₃₁H₅₄N₁₂O₇S₂
Molecular Weight	770.97g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥5 mg/mL) or 5% acetic acid; soluble in DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Possesses strong radical-scavenging activity via aromatic/sulfur-containing residues; increases SOD activity, reduces ROS levels, and enhances Y79 retinoblastoma cell viability ; useful for oxidative stress, antioxidant enzyme regulation, and cancer cell protection research
Storage Conditions	Store at -20°C ; -80°C for long-term . Avoid repeated freeze-thaw cycles; store as aliquots in sealed vials, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Antioxidant Peptide A functions through multiple, synergistic mechanisms to neutralize oxidative stress:

Direct Free Radical Scavenging: The peptide contains specific amino acid residues that can directly donate electrons or hydrogen atoms to neutralize a wide range of free radicals, including hydroxyl radicals , peroxyl radicals , and DPPH radicals, converting them into stable, non-reactive molecules.
Metal Ion Chelation: Key residues, particularly histidine (His), can effectively chelate pro-oxidant transition metal ions like Fe²⁺ and Cu²⁺. This prevents these metals from participating in Fenton/Haber-Weiss reactions, which generate highly damaging hydroxyl radicals from hydrogen peroxide.
Upregulation of Endogenous Antioxidant Defenses: Some antioxidant peptides may activate cellular defense pathways, such as the Nrf2-Keap1 pathway, leading to the increased expression of endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx).
Lipid Peroxidation Inhibition: It can protect cell membranes by intercepting lipid peroxyl radicals, thereby inhibiting the chain reaction of lipid peroxidation.

2.PRODUCT INDICATIONS

This product is indicated for research across multiple fields where oxidative stress is a key factor. Key applications include:

Antioxidant & Oxidative Stress Research: As a standard or test compound in assays measuring radical scavenging capacity (e.g., ORAC, TEAC, DPPH, FRAP), lipid peroxidation inhibition, and metal chelation.
Nutraceutical & Functional Food Research: Investigating its potential as a bioactive ingredient in dietary supplements and health-promoting foods designed to combat oxidative stress-related aging and diseases.
Cosmetic Science: As an active ingredient in anti-aging, anti-pollution, and skin-protective formulations (serums, creams) to prevent photoaging and environmental damage to the skin.
Biomedical Research: Studying its protective effects in cellular and animal models of diseases linked to oxidative stress, such as neurodegenerative disorders (Alzheimer's, Parkinson's), cardiovascular diseases, diabetes, and inflammation.
Drug Discovery & Formulation: Serving as a lead compound for developing more stable and potent antioxidant analogs or as a protective excipient.

3.CLINICAL EFFICACY OF PRODUCT

While Antioxidant Peptide A itself may not be an approved drug, a significant body of preclinical and some clinical evidence supports the efficacy of antioxidant peptides:

In Vitro & Preclinical Validation: Robust data from biochemical and cell-based assays demonstrate its potent radical scavenging and cytoprotective abilities against oxidative insults (e.g., H₂O₂, UV radiation).
Cosmetic Efficacy: In topical formulations, peptides with similar mechanisms have been clinically shown to:
- Reduce visible signs of photoaging (wrinkles, fine lines).
- Improve skin hydration and elasticity.
- Protect against pollution-induced damage.
Nutraceutical Potential: Oral administration of antioxidant peptides in studies has shown benefits in reducing systemic oxidative stress markers, supporting liver health, and improving antioxidant status in vivo.
Therapeutic Potential: Research in disease models suggests such peptides could have adjunctive benefits in conditions driven by oxidative stress, though more human clinical trials are needed for specific disease claims.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.