ACTH (2-24) CAS NO.67654-32-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | ACTH (2-24) |
| CAS NO. | 67654-32-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C133H205N39O29S1 |
| Molecular Weight | 2846.36g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water or saline solution at an appropriate pH and concentration. Soluble in dilute acid or base for small amounts. Hydrolyzed by strong acid or base. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Biologically active, capable of stimulating cortisol release from adrenal cortex cells. Activity is typically > 10 IU/mg, determined by established assays such as the rat adrenal cell bioassay. |
| Storage Conditions | Store at -20°C to -80°C in a dry environment. Avoid repeated freeze-thaw cycles. Protect from light. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
ACTH (2-24) functions by selectively binding to melanocortin type 2 receptors (MC2R) located on the surface of adrenal cortex cells. This binding activates intracellular cyclic AMP (cAMP) signaling pathways, leading to the upregulation of steroidogenic enzymes such as cholesterol side-chain cleavage enzyme (CYP11A1). As a result, it promotes the synthesis and secretion of corticosteroids, primarily cortisol, from the adrenal glands. This targeted receptor interaction enables researchers to study adrenal response mechanisms, hormone biosynthesis, and receptor-ligand dynamics without the interference of full-length ACTH's extended bioactive regions.
2.PRODUCT INDICATIONS
This peptide is indicated for experimental applications in endocrine and metabolic research, particularly in models investigating adrenal gland function, stress response systems, and corticosteroid regulation. It is used in vitro and in vivo to explore disorders like Addison's disease, Cushing's syndrome, and adrenal insufficiency. Additionally, ACTH (2-24) supports studies in neuroendocrinology, immunomodulation, and peptide pharmacology, providing insights into therapeutic strategies for hormonal imbalances and inflammatory conditions influenced by the HPA axis.
3.CLINICAL EFFICACY OF PRODUCT
In preclinical and research settings, ACTH (2-24) demonstrates significant efficacy in eliciting measurable adrenal cortisol output, validating its role as a potent ACTH receptor agonist. Studies confirm its utility in characterizing adrenal responsiveness, evaluating steroidogenic pathways, and testing potential modulators of cortisol production. Its application extends to drug discovery platforms aimed at developing treatments for adrenal dysfunctions, offering a standardized and reproducible means to assess hormonal interventions and their physiological impacts.
4.DELIVERY & SHIPPING
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