Atriopeptin I (rat) CAS NO.89139-53-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Atriopeptin I (rat) |
| CAS NO. | 89139-53-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C83H135N29O30S2 |
| Molecular Weight | 2083.31g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water or aqueous buffers (e.g., PBS, pH 7.2-7.4). For higher concentrations, initial dissolution in a minimal amount of dilute acetic acid or acetonitrile/water mixture is recommended. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Atriopeptin I (rat) corresponds to atrial natriuretic peptide (ANP) fragment 1-25. It binds to natriuretic peptide receptors (NPR-A/GC-A), stimulating cGMP production, and is used to study cardiovascular regulation, blood pressure, renal function, and natriuresis in rodent models. |
| Storage Conditions | Store desiccated at -20°C or below for long-term stability. Avoid repeated freeze-thaw cycles of reconstituted solutions. Protect from light. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Atriopeptin I (rat) exerts its biological effects by binding to and activating the natriuretic peptide receptor-A (NPR-A/GC-A), a guanylyl cyclase-coupled receptor. This binding triggers the intracellular conversion of GTP to cyclic GMP (cGMP), serving as a critical second messenger. The resulting elevation in cGMP levels leads to the relaxation of vascular smooth muscle, promotion of renal sodium and water excretion (natriuresis and diuresis), and inhibition of the renin-angiotensin-aldosterone system, collectively contributing to blood pressure reduction and fluid homeostasis.
2.PRODUCT INDICATIONS
This product is specifically indicated for preclinical research in cardiovascular and renal pharmacology. It is used extensively in vitro and in vivo to model ANP pathway activity, study mechanisms of hypertension and heart failure, and evaluate renal function. Researchers utilize Atriopeptin I (rat) in assays involving isolated blood vessels, kidney perfusion studies, cell culture systems, and animal models to dissect the pathophysiology of cardiovascular diseases and screen for potential therapeutic agents targeting the natriuretic peptide system.
3.CLINICAL EFFICACY OF PRODUCT
In experimental research settings, Atriopeptin I (rat) has demonstrated potent efficacy in eliciting characteristic physiological responses, including vasodilation, diuresis, and natriuresis in rat models. Studies consistently show its ability to lower blood pressure and modulate fluid-electrolyte balance, validating its bioactivity and reliability as a reference standard. Its use has been instrumental in defining the ANP pathway's role, providing a robust foundation for translational research aimed at developing novel treatments for conditions like hypertension and congestive heart failure.
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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