Urocortin, human

Urocortin (human) is a synthetic, 40-amino acid neuropeptide representing the endogenous human isoform. It is a high-purity research peptide belonging to the corticotropin-releasing factor (CRF) family, exhibiting high-affinity binding to both CRF1 and CRF2 receptors, with a marked preference for CRF2. This peptide is a critical tool for investigating stress responses, anxiety, cardiovascular function, and energy metabolism in human-focused and translational research models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Urocortin, human
CAS NO.	/
Appearance	Lyophilized white to off-white amorphous powder
Molecular Formula	C204H337N63O64
Molecular Weight	4696.3/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in deionized water, phosphate-buffered saline and dilute acetic acid
Endotoxin	≤1.0 EU/mg
Biological Activity	Exerts biological effects at nanomolar concentrations in human primary cell systems and preclinical models
Storage Conditions	Lyophilized powder: Long-term storage at -20°C to -80°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Urocortin exerts its effects by binding to and activating G protein-coupled corticotropin-releasing factor receptors, CRF1 and CRF2, with a significantly higher affinity for CRF2. Upon receptor activation, it primarily stimulates the Gs signaling pathway, leading to increased adenylate cyclase activity and elevated intracellular cyclic AMP (cAMP) levels.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in neuroendocrinology, psychiatry, cardiovascular biology, and metabolism. Key applications include: studying the distinct roles of CRF receptor subtypes in stress-related disorders and anxiety; investigating urocortin's cardioprotective and vasodilatory effects in models of heart failure; exploring its anorexigenic (appetite-suppressing) actions and role in energy homeostasis; and serving as the definitive human reference agonist in receptor binding, signaling, and functional assays for drug discovery targeting the CRF system.

3.CLINICAL EFFICACY OF PRODUCT

Human Urocortin is a research peptide and not an approved drug. However, its strong therapeutic potential has been demonstrated in preclinical and early clinical studies. Research indicates significant promise for treating acute decompensated heart failure due to its beneficial hemodynamic effects (increased cardiac output and vasodilation).

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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