Substance P, Free Acid CAS NO.71977-09-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Substance P, Free Acid |
| CAS NO. | 71977-09-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C63H97N17O14S |
| Molecular Weight | 1348.65g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg (by LAL test, typical for research-grade peptides) |
| Biological Activity | Binds to and activates the neurokinin 1 receptor (NK1R), a G protein-coupled receptor. It is a potent vasodilator and mediator of neurogenic inflammation, pain transmission, and emesis. |
| Storage Conditions | Binds to and activates the neurokinin 1 receptor (NK1R), a G protein-coupled receptor. It is a potent vasodilator and mediator of neurogenic inflammation, pain transmission, and emesis. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide primarily acts as an agonist at the G protein-coupled neurokinin-1 receptor (NK1R), though with potentially altered affinity and potency compared to the amidated form. Upon binding, it activates phospholipase C, leading to increased inositol triphosphate and diacylglycerol production, which elevates intracellular calcium and triggers downstream signaling pathways responsible for mediating pain transmission, neurogenic inflammation, smooth muscle contraction, and emetic responses.
2.PRODUCT INDICATIONS
Substance P, Free Acid is indicated for research applications in neuroscience, pharmacology, and biochemistry, including studies of tachykinin receptor signaling, structure-activity relationship investigations, enzyme degradation assays, and as a control or substrate in mass spectrometry and HPLC analysis. It is also used in models of inflammation, pain, and gastrointestinal motility where the effects of C-terminal modifications on biological activity are being explored.
3.CLINICAL EFFICACY OF PRODUCT
As a research-grade analog, Substance P, Free Acid has no established clinical efficacy or therapeutic application. Its role is confined to preclinical research, where it aids in understanding Substance P biology and metabolism. This knowledge contributes to the development of NK1R antagonists, which are clinically approved for preventing chemotherapy-induced nausea and vomiting, though the free acid peptide itself is not used in treatment.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
