Neurotensin (8-13), N-Acetyl CAS NO.74853-69-3

Neurotensin (8-13), N-Acetyl is a synthetic hexapeptide fragment corresponding to residues 8-13 of full-length neurotensin, featuring N-terminal acetylation and supplied as a lyophilized powder with ≥95% HPLC purity. This research-grade peptide represents the minimal bioactive core of neurotensin, retaining high receptor affinity while offering improved metabolic stability compared to the native sequence. It serves as a potent and selective tool for studying neurotensin receptor signaling in neuroscience, pain research, and gastrointestinal physiology, providing researchers with a reliable reagent for in vitroand in vivopreclinical investigations.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurotensin (8-13), N-Acetyl
CAS NO.	74853-69-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C40H66N12O9
Molecular Weight	859.05g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This N‑acetylated fragment retains high affinity for neurotensin receptors (NTSR1, NTSR2) and is a potent neurotensin agonist. It elicits characteristic neurotensin‑like effects, such as hypothermia, analgesia, and modulation of dopamine transmission. Bioactivity can be validated in receptor binding assays or functional assays (e.g., calcium flux in NTSR‑expressing cells).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neurotensin (8-13), N-Acetyl exerts its biological effects by binding with high affinity to neurotensin receptors NTSR1 and NTSR2, primarily coupling to Gq/11 proteins to activate phospholipase C and increase intracellular calcium mobilization. This signaling cascade modulates neuronal excitability, dopamine transmission, and nociceptive processing in the central nervous system, while also influencing gastrointestinal motility and secretion in peripheral tissues. The N-terminal acetylation enhances peptide stability by reducing enzymatic degradation, prolonging its half-life and pharmacological activity in experimental systems without significantly altering receptor selectivity.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications focused on neurotensin receptor signaling, central nervous system function, and gastrointestinal physiology. It is utilized in in vitroassays with NTSR-expressing cells to study receptor binding, calcium flux, and intracellular signaling pathways. In in vivostudies, it is administered to investigate neurotensin-mediated effects on pain perception, thermoregulation, dopamine transmission, and gut motility in preclinical models. The product also serves as a reference standard for receptor autoradiography, immunohistochemistry, and functional assays to explore the role of neurotensin in neurological disorders, pain conditions, and gastrointestinal diseases.

3.CLINICAL EFFICACY OF PRODUCT

Neurotensin (8-13), N-Acetyl has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its potent analgesic, hypothermic, and dopamine-modulating effects, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of stable analogs or formulations with comprehensive pharmacokinetic and safety evaluations.

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