Neurotensin (8-13), N-Acetyl CAS NO.74853-69-3
Neurotensin (8-13), N-Acetyl CAS NO.74853-69-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neurotensin (8-13), N-Acetyl |
| CAS NO. | 74853-69-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C40H66N12O9 |
| Molecular Weight | 859.05g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This N‑acetylated fragment retains high affinity for neurotensin receptors (NTSR1, NTSR2) and is a potent neurotensin agonist. It elicits characteristic neurotensin‑like effects, such as hypothermia, analgesia, and modulation of dopamine transmission. Bioactivity can be validated in receptor binding assays or functional assays (e.g., calcium flux in NTSR‑expressing cells). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Neurotensin (8-13), N-Acetyl exerts its biological effects by binding with high affinity to neurotensin receptors NTSR1 and NTSR2, primarily coupling to Gq/11 proteins to activate phospholipase C and increase intracellular calcium mobilization. This signaling cascade modulates neuronal excitability, dopamine transmission, and nociceptive processing in the central nervous system, while also influencing gastrointestinal motility and secretion in peripheral tissues. The N-terminal acetylation enhances peptide stability by reducing enzymatic degradation, prolonging its half-life and pharmacological activity in experimental systems without significantly altering receptor selectivity.
2.PRODUCT INDICATIONS
This peptide is indicated for research applications focused on neurotensin receptor signaling, central nervous system function, and gastrointestinal physiology. It is utilized in in vitroassays with NTSR-expressing cells to study receptor binding, calcium flux, and intracellular signaling pathways. In in vivostudies, it is administered to investigate neurotensin-mediated effects on pain perception, thermoregulation, dopamine transmission, and gut motility in preclinical models. The product also serves as a reference standard for receptor autoradiography, immunohistochemistry, and functional assays to explore the role of neurotensin in neurological disorders, pain conditions, and gastrointestinal diseases.
3.CLINICAL EFFICACY OF PRODUCT
Neurotensin (8-13), N-Acetyl has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its potent analgesic, hypothermic, and dopamine-modulating effects, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of stable analogs or formulations with comprehensive pharmacokinetic and safety evaluations.
4.DELIVERY & SHIPPING
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