Saposin C22
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Saposin C22 |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C116H196N28O37S |
| Molecular Weight | 2607.08g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS, or dilute acetic acid. It is recommended to dissolve in sterile water or buffer to prepare stock solutions for biological assays. |
| Endotoxin | < 1.0 EU/mg (Typical for research-grade peptides) |
| Biological Activity | Saposin C22 is a potent vasoconstrictor and bronchoconstrictor. It acts as a selective agonist for the endothelin B (ETB) receptor, making it a valuable tool for studying endothelin receptor pharmacology and vascular physiology. |
| Storage Conditions | Store at -20°C or lower. For long-term storage, keep desiccated at -20°C. Upon reconstitution, aliquot and store at -20°C to avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Saposin C22 functions by binding to glucocerebrosidase (GCase) and facilitating its interaction with lipid substrates within the lysosomal membrane. It acts as a co-factor that enhances the enzymatic activity of GCase, promoting the hydrolysis of glucosylceramide into glucose and ceramide. This mechanism is crucial for maintaining lipid homeostasis and preventing the accumulation of toxic lipid species in cells.
2.PRODUCT INDICATIONS
This product is indicated for use in preclinical research to investigate the role of saposin C in lysosomal biology and lipid metabolism. It is employed in studies focusing on Gaucher disease, Parkinson's disease (where GCase dysfunction is implicated), and other lysosomal storage disorders. Additionally, it is used to screen for potential therapeutic agents that modulate GCase activity.
3.CLINICAL EFFICACY OF PRODUCT
While Saposin C22 is not approved for clinical use, research demonstrates its efficacy in restoring GCase activity in cellular models of Gaucher disease. Studies show that supplementation with saposin C can rescue enzyme function in cells with deficient GCase activity, reducing lipid accumulation and improving lysosomal function. These findings support its potential as a therapeutic candidate for disorders involving GCase impairment.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
