Hepatitis B Virus Receptor Binding Fragment
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Hepatitis B Virus Receptor Binding Fragment |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C140H185N35O42 |
| Molecular Weight | 3030.2g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS, or dilute acetic acid. It is recommended to dissolve in sterile water or buffer to prepare stock solutions for biological assays. |
| Endotoxin | < 1.0 EU/mg (Typical for research-grade peptides) |
| Biological Activity | The Hepatitis B Virus Receptor Binding Fragment is a synthetic peptide designed to mimic the preS1 domain of the Hepatitis B virus surface protein. It specifically binds to the sodium taurocholate cotransporting polypeptide (NTCP) receptor on hepatocytes, serving as a critical tool for studying viral entry mechanisms and screening for entry inhibitors. |
| Storage Conditions | Store at -20°C or lower. For long-term storage, keep desiccated at -20°C. Upon reconstitution, aliquot and store at -20°C to avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This fragment functions as the key region of the HBV envelope protein that recognizes and binds to the host cell receptor, such as NTCP. This interaction initiates viral entry by facilitating membrane fusion, allowing the virus to deliver its genetic material into hepatocytes and commence replication.
2.PRODUCT INDICATIONS
This product is intended for research use only and is not for human or animal clinical diagnosis or therapy. It is utilized in studies related to infection, anti-HBV signaling pathways, and inflammation/immunology to investigate viral entry mechanisms and develop novel therapeutic strategies.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, this fragment is not approved for clinical use. However, studies demonstrate its potential in eliciting protective antibodies that block virus-receptor binding, offering a foundation for developing novel vaccines and entry inhibitors aimed at preventing HBV infection.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
