Cortistatin 14 (mouse, rat) CAS NO. 186901-48-4
Cortistatin 14 (mouse, rat) CAS NO. 186901-48-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Cortistatin 14 (mouse, rat) |
| CAS NO. | 186901-48-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₈₁H₁₁₃N₁₉O₁₉S₂ |
| Molecular Weight | 1721.01 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (~100 mg/mL) or 1% acetic acid (1 mg/mL); clear, colorless solution |
| Endotoxin | < 1.0 EU/mg (Typical for research-grade peptides) |
| Biological Activity | Binds to somatostatin receptors (sst₁-sst₅) and ghrelin receptor; exhibits neuronal depressant, anti-inflammatory, and anticonvulsant properties |
| Storage Conditions | -20°C (desiccated, sealed); avoid repeated freeze-thaw cycles; stock solutions stable at -80°C for 6 months. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Somatostatin Receptor (sst) Activation: Like somatostatin, it binds to and activates sst1-5 receptors, which are coupled to Gi/o proteins. This leads to inhibition of adenylyl cyclase, reduced cAMP levels, and modulation of calcium and potassium channels. This pathway mediates effects such as neuronal inhibition and reduced hormone secretion.
- Ghrelin Receptor (GHS-R1a) Interaction: A defining feature of cortistatin is its ability to bind to and act as an agonist or modulator at the GHS-R1a receptor. This interaction is implicated in its specific effects on sleep regulation, locomotor activity, and appetite, differentiating it from somatostatin.
- Immunomodulation: It has potent anti-inflammatory and immunosuppressive effects on T-cells and macrophages, which are relevant to autoimmune disease and inflammation research.
- Neuroscience Research: Studying its role in sleep-wake cycles, cortical excitability, locomotor activity, and neuroprotection in rodent models.
- Immune System Modulation: Investigating its potent anti-inflammatory and immunosuppressive effects on T-cells and macrophages in models of autoimmune disease and inflammation.
- Endocrine Research: Exploring its effects on growth hormone release and other pituitary functions, often in comparison to somatostatin.
- Receptor Specificity Studies: Used to differentiate the roles of somatostatin receptors versus the ghrelin receptor in various physiological processes.
- Target Validation: Studies with Cortistatin 14 have highlighted its unique anti-inflammatory and neuroprotective properties, suggesting that cortistatin-based therapies or GHS-R1a modulators could be developed for conditions like rheumatoid arthritis, multiple sclerosis, and neurodegenerative diseases.
- Biomarker Potential: Its expression patterns are being investigated as potential biomarkers for certain neurological and inflammatory disorders.
Drug Discovery: It serves as the key reference compound for screening and developing novel, selective agonists or antagonists for the cortistatin/ghrelin receptor pathways in preclinical rodent models.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
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Shipping Methods
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