CREBtide CAS NO. 149155-45-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | CREBtide |
| CAS NO. | 149155-45-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C73H127N29O18 |
| Molecular Weight | 1699.01 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥1 mg/mL); also soluble in aqueous buffers . |
| Endotoxin | <0.1 EU/μg (Typical for research-grade peptides) |
| Biological Activity | Synthetic peptide substrate for PKA (cAMP-dependent protein kinase) and PKC; based on the phosphorylation motif of δ‑CREB (cAMP response element‑binding protein). |
| Storage Conditions | Lyophilized powder: −20°C (stable for ≥12 months); reconstituted solution: aliquot and store at −20°C, avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
CREBtide functions as a competitive substrate for protein kinases. It contains a specific serine residue that is phosphorylated by PKA. The peptide mimics the natural phosphorylation site of CREB, allowing researchers to quantify kinase activity by measuring the incorporation of phosphate groups into the peptide. Its mechanism involves binding to the active site of PKA, where it undergoes phosphorylation at a much higher rate and with greater affinity (lower Km) compared to other common substrates like Kemptide.
2.PRODUCT INDICATIONS
- Kinase Activity Assays: Used as a high-affinity substrate to measure the activity of PKA in cell lysates or purified enzyme preparations.
- Signal Transduction Studies: Employed to investigate the cAMP/PKA signaling pathway and its role in gene expression regulation.
- Drug Screening: Utilized in high-throughput screening assays to identify inhibitors or activators of PKA
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, CREBtide is not used directly in clinical therapy. However, its utility lies in its role as a diagnostic and research tool. By providing a sensitive and specific means to measure PKA activity, it contributes to the understanding of diseases where PKA signaling is dysregulated, such as certain cancers, metabolic disorders, and neurological conditions. Its high specificity (cAK/cGK) makes it a valuable tool for validating the efficacy of experimental drugs targeting the PKA pathway in preclinical research
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
