Corticotropin Releasing Factor, human, rat CAS NO.86784-80-7

Corticotropin Releasing Factor (CRF), human, rat is a synthetic, high-purity 41-amino acid neuropeptide (Sequence: H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2) with a molecular weight of 4757.45 g/mol. It is a master regulator of the hypothalamic-pituitary-adrenal (HPA) axis and is identical in sequence for both human and rat species, making it an essential tool for translational research in stress, neuroendocrinology, and psychiatric disorders. This product is supplied as a lyophilized powder for research use only.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Corticotropin Releasing Factor, human, rat
CAS NO.	86784-80-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C208H344N60O63S2
Molecular Weight	4575.5g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in sterile water (1.0–1.1 mg/mL, clear solution); soluble in 5% NH₄OH or dilute acetic acid for improved dissolution.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Potent endogenous agonist for CRF receptors . Stimulates the synthesis and release of adrenocorticotropic hormone (ACTH) and β-endorphin from the anterior pituitary. Induces hypothalamic-pituitary-adrenal (HPA) axis activation in stress response models.
Storage Conditions	Lyophilized powder: Store at -20°C (desiccated) for 12–24 months stability. Reconstituted solution: Aliquot and store at -20°C; avoid repeated freeze-thaw cycles .
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

CRF acts as the primary stimulator of the HPA axis. It binds to specific G-protein coupled receptors (CRF-R1 and CRF-R2) on corticotroph cells in the anterior pituitary, activating adenylate cyclase and increasing intracellular cAMP levels. This cascade stimulates the synthesis and secretion of adrenocorticotropic hormone (ACTH), which subsequently drives the adrenal cortex to release cortisol (in humans) or corticosterone (in rodents). Beyond the pituitary, CRF acts as a neurotransmitter in the central nervous system, influencing autonomic functions, behavior, and the immune response.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research applications, including:

Stress Response Studies: Investigation of the physiological and behavioral effects of stress.
Neuroendocrinology: Elucidation of HPA axis regulation and feedback mechanisms.
Psychiatric Research: Modeling of anxiety, depression, and addiction, where CRF systems are often dysregulated.
Immunology: Study of the interactions between the neuroendocrine and immune systems, as CRF is expressed in lymphoid tissues.
Diagnostic Tool Development: As a standard for developing assays to measure endogenous CRF levels.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, CRF is not used directly in human therapy. However, its clinical relevance is demonstrated through its use in diagnostic tests. The CRF Stimulation Test is a standard clinical tool used to differentiate between Cushing's disease, ectopic ACTH syndrome, and adrenal insufficiency. In research models, administration of CRF has been shown to produce anxiety-like behaviors and activate stress pathways, validating its role in the pathophysiology of stress-related disorders. Antagonists of the CRF receptor, developed using compounds like this peptide, are under investigation for the treatment of depression and anxiety.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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