Dynorphin A (13-17), porcine
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Dynorphin A (13-17), porcine |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C30H43N9O10 |
| Molecular Weight | 689.73g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in distilled water (clear solution at 1 mg/mL); soluble in aqueous buffers (PBS, 0.1% TFA); sparingly soluble in organic solvents. |
| Endotoxin | < 1.0 EU/mg (Typical for research-grade peptides) |
| Biological Activity | Core C-terminal fragment of the full-length Dynorphin A peptide. Retains affinity for κ-opioid receptors (KOR). Plays a role in modulating pain signaling, neurotransmitter release, and neuronal excitability. Serves as a key structural motif for opioid receptor interaction. |
| Storage Conditions | Lyophilized powder: Store at -20°C (desiccated) for 12–24 months. Reconstituted solution: Aliquot and store at -20°C; avoid repeated freeze-thaw cycles (stable for 1 month). |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide exerts its effects primarily through binding to the κ-opioid receptor (KOR), which is a G-protein coupled receptor (GPCR). Upon binding, it inhibits adenylate cyclase activity, leading to a reduction in intracellular cAMP levels. Additionally, it modulates calcium and potassium ion channels, resulting in hyperpolarization of neurons and a subsequent decrease in neurotransmitter release. This mechanism underlies its analgesic and neuroprotective properties, distinguishing it from mu-opioid agonists like morphine.
2.PRODUCT INDICATIONS
- Neuroscience Research: Investigating pain pathways, stress responses, and neuroprotection.
- Pharmacology: Screening for novel analgesic compounds and studying opioid receptor interactions.
- Biochemistry: Analyzing peptide-receptor binding affinity and specificity.
- Cell Signaling: Exploring intracellular cascades activated by KOR stimulation.
3.CLINICAL EFFICACY OF PRODUCT
While Dynorphin A fragments are not approved for direct therapeutic use in humans, preclinical studies demonstrate significant analgesic efficacy without the typical euphoric effects associated with mu-opioid agonists. Its selective action on KORs suggests potential for developing non-addictive pain therapeutics and treatments for addiction disorders. Research indicates it may also play a role in modulating mood and stress responses, highlighting its therapeutic potential beyond analgesia.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
