[Ala144] – PLP (139 – 151) A144 – PLP(139 – 151)

[Ala144] – PLP (139 – 151) is a synthetic altered peptide ligand (APL) derived from the myelin proteolipid protein, specifically designed as a non-encephalitogenic analog of the native PLP 139-151 epitope. This product is engineered to modulate immune responses by altering T-cell receptor (TCR) recognition, making it a critical tool for studying immune tolerance and autoimmune disease mechanisms in experimental models such as experimental autoimmune encephalomyelitis (EAE).

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Ala144] – PLP (139 – 151) A144 – PLP(139 – 151)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C64H99N19O17
Molecular Weight	1406.62g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water or aqueous buffers. For best results, prepare a stock solution in sterile water or PBS and aliquot to avoid repeated freeze-thaw cycles.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Exhibits biological activity consistent with the PLP fragment. Specific activity may vary depending on the assay system and experimental conditions.
Storage Conditions	Store lyophilized powder at -20°C or below. For long-term storage, keep at -80°C. Protect from light and moisture. Reconstituted solutions should be stored at -20°C or -80°C in single-use aliquots.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The mechanism of action involves a single amino acid substitution at position 144, where tryptophan is replaced by alanine. This modification disrupts the primary TCR contact point, preventing the activation of pathogenic Th1 cells that drive autoimmunity. Instead, the peptide induces a shift in T-cell differentiation towards a protective Th2 phenotype, characterized by the production of anti-inflammatory cytokines like IL-4 and IL-10, thereby promoting immune deviation and suppression of autoimmune responses.

2.PRODUCT INDICATIONS

This product is indicated for use in immunological research focused on autoimmune diseases, particularly multiple sclerosis (MS) research using the EAE model. It is utilized to investigate antigen-specific tolerance, T-cell repertoire dynamics, and the therapeutic potential of altered peptide ligands in preventing or treating demyelinating diseases.

3.CLINICAL EFFICACY OF PRODUCT

In preclinical studies, [Ala144] – PLP (139 – 151) has demonstrated significant efficacy in preventing the development and progression of EAE. Administration of this APL has been shown to confer protection against disease induction, reduce clinical severity, and inhibit the effector phase of EAE by modulating the cytokine profile and expanding regulatory T-cell populations.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.