α-Endorphin CAS NO.59004-96-5

α-Endorphin is a 16-amino acid endogenous neuropeptide derived from the proteolytic cleavage of proopiomelanocortin (POMC). It is a fragment of β-Endorphin (1-16) and is known for its opioid-like activity, primarily acting on μ-opioid receptors. This peptide is involved in modulating pain perception, stress responses, and mood regulation. It is supplied as a high-purity, lyophilized powder for research use in neurobiology and pharmacology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	α-Endorphin
CAS NO.	59004-96-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C77H120N18O26S
Molecular Weight	1745.98 g/mol
Purity (RP-HPLC)	≥97%
Solubility	Soluble in water, PBS, or dilute acetic acid. It is recommended to dissolve in sterile water or buffer to prepare stock solutions for biological assays.
Endotoxin	≤50 EU/mg (Typical for research-grade peptides)
Biological Activity	Endogenous opioid peptide derived from pro-opiomelanocortin (POMC). Acts as a weak agonist for μ-opioid receptors (MOR). Modulates pain perception, mood, and neuroendocrine function. Less potent analgesic compared to β-endorphin.
Storage Conditions	Lyophilized powder: Store at -20°C (desiccated) for 12–24 months. Reconstituted solution: Aliquot and store at -20°C; avoid repeated freeze-thaw cycles (stable for ≥1 month).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

α-Endorphin functions as an opioid receptor agonist, with a primary affinity for the μ-opioid receptor (MOR). Its mechanism involves:

Receptor Binding: It binds to G-protein coupled opioid receptors in the central nervous system.
Signal Transduction: Activation of these receptors inhibits adenylate cyclase, reducing intracellular cAMP levels.
Neuronal Effects: This leads to hyperpolarization of neurons, inhibition of neurotransmitter release (e.g., GABA), and modulation of pain signals. Unlike β-Endorphin, α-Endorphin has a shorter half-life and may exhibit different behavioral effects, often associated with psychomotor stimulation rather than sedation.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research applications, including:

Neuroscience: Study of endogenous opioid systems, pain pathways, and reward mechanisms.
Psychopharmacology: Investigation of its role in mood disorders, stress, and addiction.
Immunology: Research into the interactions between the opioid system and immune function (e.g., cytokine modulation).
Receptor Assays: Used as a ligand in binding studies to characterize opioid receptor subtypes.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, α-Endorphin is not used directly in clinical therapy. However, its physiological role is significant. Studies suggest that α-Endorphin may have psychostimulant properties, potentially increasing locomotor activity and alertness, which contrasts with the sedative effects of longer endorphin fragments. Its rapid metabolism limits its therapeutic potential, but understanding its action helps in developing drugs that target specific aspects of the opioid system for pain management or psychiatric conditions.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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