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Parathyroid Hormone (70-84), human CAS NO.213533-86-9

Parathyroid Hormone (70-84), human is a synthetic peptide fragment derived from the carboxyl-terminal region of the full-length parathyroid hormone (PTH). This specific fragment is primarily utilized in research settings to study the non-classical actions of PTH, particularly its effects on bone metabolism and calcium homeostasis that are distinct from the actions mediated by the N-terminal region. It serves as a critical tool for investigating the complex signaling pathways of PTH and for developing diagnostic assays.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Parathyroid Hormone (70-84), human
CAS NO.	213533-86-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C67H118N20O24
Molecular Weight	1587.79g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water or aqueous buffers. For best results, prepare a stock solution in sterile water or PBS and aliquot to avoid repeated freeze-thaw cycles.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Exhibits biological activity consistent with the PTH fragment. Specific activity may vary depending on the assay system and experimental conditions.
Storage Conditions	Store lyophilized powder at -20°C or below. For long-term storage, keep at -80°C. Protect from light and moisture. Reconstituted solutions should be stored at -20°C or -80°C in single-use aliquots.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The mechanism of action of Parathyroid Hormone (70-84) involves its interaction with specific receptors distinct from the classical PTH1R. While the N-terminal fragment (1-34) is known for its anabolic effects on bone via cAMP signaling, the C-terminal fragments, including (70-84), are believed to exert their effects through different pathways, potentially influencing osteoclast activity and bone resorption. This fragment may also play a role in the clearance and metabolism of the hormone, contributing to the overall regulation of calcium and phosphate balance in the body.

2.PRODUCT INDICATIONS

This product is indicated for use in scientific research focused on endocrinology and bone biology. It is employed in studies investigating the pathophysiology of hyperparathyroidism and hypoparathyroidism, as well as in the development of immunoassays for measuring PTH levels in clinical diagnostics. Researchers use this fragment to understand the role of C-terminal PTH fragments in chronic kidney disease and metabolic bone disorders.

3.CLINICAL EFFICACY OF PRODUCT

In clinical research contexts, the Parathyroid Hormone (70-84) fragment has been shown to be valuable for diagnostic purposes, particularly in distinguishing between different forms of hyperparathyroidism. Studies utilizing this fragment have contributed to the understanding of PTH metabolism, showing that C-terminal fragments accumulate in renal failure and can be used as markers for disease progression. Its efficacy in research has led to improved assay specificity for intact PTH measurements.

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