Chrysosplenetin CAS NO.603-56-5
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Chrysosplenetin |
| Synonyms | / |
| CAS NO. | 603-56-5 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C19H18O8 |
| Molecular Weight | 374.34 g/mol |
| Amino Acid Sequence | Not applicable (Non-peptide compound) |
| Purity (RP-HPLC) | ≥ 98.0% |
| Purity (SEC-HPLC) | ≥ 99.0% (monomer content) |
| Solubility | Soluble in DMSO, methanol, and ethanol; slightly soluble in water |
| Endotoxin | < 1 EU/mg (or Not detected) |
| Biological Activity | Exhibits anti-inflammatory, anticancer, and multidrug resistance reversal activities; inhibits P-glycoprotein and modulates PI3K/AKT and MAPK pathways |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
Garcinone D
1.MECHANISM OF ACTION
Chrysosplenetin exerts its effects by acting as a potent inhibitor of P-glycoprotein (P-gp) and modulating the PI3K/AKT-mTOR and MAPK signaling pathways. It disrupts the heme-ROS/GSH axis and inhibits the efflux function of ABC transporters, thereby reversing multidrug resistance. Additionally, it induces apoptosis and autophagy in cancer cells by regulating key proteins such as Bcl-2 and caspases, making it effective against various cancer cell lines.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
In vivo studies demonstrate that Chrysosplenetin effectively reduces tumor growth in prostate cancer models and protects against LPS-induced acute lung injury by inhibiting oxidative stress and inflammation. It shows promising results in reversing artemisinin resistance in malarial parasites and exhibits significant efficacy in inducing apoptosis in oral cancer cells, supporting its potential as a therapeutic agent for inflammatory and neoplastic diseases.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Chrysosplenetin, Natural Product, Polymethoxy Flavonol, Anti-inflammatory, Anticancer, Antioxidant, Apoptosis, P-gp inhibitor, PI3K/AKT inhibitor, MAPK inhibitor, Artemisia annua, Research Chemical, Cytotoxic, Drug Resistance Reversal, Homeostasis Stabilizer
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
