TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Licochalcone D exerts its biological effects primarily by acting as a potent inhibitor of the NF-κB signaling pathway, specifically by suppressing the phosphorylation of the p65 subunit, which prevents the translocation of this transcription factor to the nucleus and the subsequent expression of pro-inflammatory cytokines. Additionally, it modulates key kinases including JAK2, EGFR, and MET, leading to the induction of reactive oxygen species (ROS)-dependent apoptosis through the activation of caspases and cleavage of PARP, thereby disrupting cell cycle progression and promoting programmed cell death in malignant cells.

2.PRODUCT INDICATIONS

This product is indicated for use in scientific research targeting a range of pathological conditions, including inflammatory diseases such as LPS-induced sepsis models, various cancer types like colorectal cancer and melanoma, and metabolic disorders. It is particularly relevant for researchers investigating the mechanisms of skin carcinogenesis, osteoclast differentiation in osteoporosis, and neuroprotection against oxidative stress, making it a versatile compound for pharmacologists, oncologists, and immunologists seeking to validate natural product-based therapeutic strategies.

3.CLINICAL EFFICACY OF PRODUCT

While Licochalcone D is currently designated for research purposes only and not for direct human clinical use, preclinical studies have demonstrated significant efficacy in animal models. Research has shown its ability to alleviate MRSA-induced pneumonia by modulating macrophage ferroptosis, protect against radiation-induced intestinal injury via Sirt3-dependent mitophagy, and inhibit tumor growth and metastasis in xenograft models, highlighting its potential as a lead compound for the future development of anti-infective, radioprotective, and chemopreventive agents.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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