Lanosterol CAS NO.79-63-0

Lanosterol CAS NO.79-63-0

Lanosterol  CAS NO.79-63-0

Lanosterol CAS NO.79-63-0

Lanosterol CAS NO.79-63-0

Lanosterol is a key tetracyclic triterpenoid and the first committed sterol intermediate in the cholesterol biosynthesis pathway. It is biosynthesized from squalene-2,3-epoxide via enzymatic cyclization. As a central precursor, Lanosterol is essential for the production of all animal and fungal sterols, including cholesterol, steroid hormones, and vitamin D. It is primarily recognized for its critical role in cellular membrane structure and as a biosynthetic building block in pharmaceutical and cosmetic industries.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Lanosterol
CAS NO.
79-63-0
Appearance
White to off-white crystalline powder
Molecular Formula
C₃₀H₅₀O
Molecular Weight
426.72 g/mol
Purity (RP-HPLC)
≥98%
Solubility
Practically insoluble in water; soluble in chloroform, ether, ethanol, and other organic solvents (e.g., DMSO, methanol)
Endotoxin
<0.1 EU/mg
Biological Activity
Key intermediate in cholesterol biosynthesis; precursor to all animal steroids; studied for potential anti-cataract and anti-inflammatory effects in preclinical research.
Storage Conditions
Sealed container, stored at 2–8°C (refrigerated), protected from light, moisture, and air; avoid repeated freeze-thaw cycles
Stock Location
Stock in USA
MOQ
10g


1.MECHANISM OF ACTION

  • In biosynthesis, Lanosterol undergoes a series of demethylation, reduction, and isomerization reactions catalyzed by enzymes (e.g., CYP51A1) to form cholesterol. Beyond its precursor function, Lanosterol has been identified as a potent agent in reversing protein aggregation. Research indicates it can bind to and solubilize misfolded proteins, such as crystallins in the eye lens, thereby reducing cataract formation. Its action involves penetrating cell membranes and directly interacting with aggregated proteins to promote their disaggregation.

  • 2.PRODUCT INDICATIONS

Lanosterol is indicated for use as a high-value intermediate in the synthesis of steroid drugs (e.g., hormones, corticosteroids) and vitamin D analogs. In ophthalmic research and formulation, it is used in studies and products targeting cataract prevention and treatment. Additionally, it finds application in cosmetic and skincare products for its potential anti-aging and cell membrane-stabilizing properties, as well as in biochemical research as a standard or substrate for enzyme studies.

    3.CLINICAL EFFICACY OF PRODUCT

    In vitro and in vivo studies, particularly on lens organ cultures and animal models, have demonstrated Lanosterol's efficacy in significantly reducing the size and opacity of protein aggregates associated with cataracts. Clinical research is ongoing, with preliminary evidence supporting its potential as a therapeutic agent for age-related and congenital cataracts, potentially offering a non-surgical intervention. Its role in maintaining lens transparency and cellular homeostasis underscores its therapeutic promise in ophthalmology.

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