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Polyphyllin III CAS NO.19057-60-4

Polyphyllin III is a high-purity natural steroidal saponin extracted from the traditional medicinal herb Paris polyphylla(Chonglou), widely utilized in cancer research and pharmaceutical development. This bioactive compound is characterized by its potent antitumor activity, ability to induce multiple modes of cell death, and relatively low cytotoxicity to normal cells, making it a valuable reference standard and a promising lead compound for new drug discovery. It is primarily used by researchers and pharmaceutical developers focusing on oncology, particularly in the study of aggressive and drug-resistant cancer models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Polyphyllin III
CAS NO.	19057-60-4
Appearance	White to off-white powder
Molecular Formula	C45H72O16
Molecular Weight	869.04 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water
Endotoxin	≤ 10 EU/mg
Biological Activity	Anticancer, induces apoptosis and ferroptosis, inhibits STAT3 and PI3K/AKT pathways
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Polyphyllin III exerts its anticancer effects through a multi-target mechanism, primarily by inducing ferroptosis—an iron-dependent form of regulated cell death driven by the accumulation of lipid peroxides and the suppression of the xCT/GPX4 antioxidant axis. It also promotes apoptosis via mitochondrial dysfunction and cell cycle arrest, while simultaneously inhibiting cancer cell metastasis by modulating key signaling pathways such as GSK-3β/β-catenin and EMT-related markers. This multifaceted action makes it particularly effective against tumors with resistance to conventional therapies.

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2.PRODUCT INDICATIONS

This product is indicated for preclinical research and screening applications targeting a broad spectrum of malignancies, including triple-negative breast cancer (TNBC), lung cancer, gastric cancer, and liver cancers. It is suitable for studies on tumor proliferation inhibition, metastasis suppression, and reversal of chemoresistance. The primary user base includes academic research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in the development of natural product-derived anticancer agents or adjuvant therapies.

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3.CLINICAL EFFICACY OF PRODUCT

Extensive in vitro and in vivo studies have demonstrated that Polyphyllin III significantly inhibits tumor growth and metastasis with a favorable safety profile. Animal model research shows it effectively reduces tumor volume and weight in xenograft models of breast and lung cancer, often with minimal impact on body weight, indicating low systemic toxicity. While human clinical trials are still in the exploratory stage, the robust preclinical data positions it as a strong candidate for further translational development, especially in combination therapy regimens to enhance the efficacy of existing chemotherapeutic drugs.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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