Andrograpanin CAS NO.82209-74-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Andrograpanin |
| CAS NO. | 82209-74-3 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₂₀H₃₀O₅ |
| Molecular Weight | 350.45 g/mol |
| Amino Acid Sequence | β-Ala-His |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in DMSO, ethanol, methanol, and chloroform; sparingly soluble in water |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Exhibits anti-inflammatory, anti-viral, anti-bacterial, and anti-tumor activities; modulates immune response and protects against oxidative stress |
| Storage Conditions | - Powder: Store at 2–8°C (short-term) or -20°C (long-term), sealed, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
Andrograpanin exerts its effects through the modulation of pivotal cellular signaling pathways. A primary mechanism involves the potent inhibition of the NF-κB pathway, leading to the downregulation of pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β) and enzymes like COX-2 and iNOS. It activates the Nrf2 antioxidant pathway, enhancing the expression of protective enzymes like HO-1. Additionally, it can induce apoptosis in cancer cells via mitochondrial pathways and modulate immune responses, contributing to its broad-spectrum bioactivity.
2.PRODUCT INDICATIONS
Andrograpanin is indicated for use in advanced pharmacological and biomedical research. Its primary applications are as a lead compound in the development of anti-inflammatory and neuroprotective agents. It is actively studied for therapeutic potential in conditions such as neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), liver injury/diseases, inflammatory disorders (e.g., arthritis, colitis), and certain cancers. It also serves as a high-purity reference standard for the quality control of Andrographis paniculataextracts and related herbal products.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical in vitro and in vivo studies robustly demonstrate the efficacy of andrograpanin. Research shows it effectively reduces inflammation and tissue damage in models of colitis, hepatitis, and neurodegenerative conditions. In neuroprotection, it mitigates neuronal apoptosis and improves cognitive function in animal models. Its hepatoprotective effects are evidenced by reduced serum enzyme levels and histopathological improvements in liver injury models. Anticancer studies indicate it inhibits proliferation and induces apoptosis in various cancer cell lines, supporting its promise as a multifaceted therapeutic candidate.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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