Notoginsenoside R1 CAS NO.80418-24-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Notoginsenoside R1 |
| CAS NO. | 80418-24-2 |
| Appearance | White to off-white fine powder or crystalline powder |
| Molecular Formula | C₄₇H₈₀O₁₈ |
| Molecular Weight | 933.13 g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in methanol, ethanol, DMSO; sparingly soluble in water; insoluble in petroleum ether, n-hexane |
| Endotoxin | <0.05 EU/mg |
| Biological Activity | - Anti-inflammatory and immunomodulatory effects- Neuroprotective activity- Antioxidant properties- Cardiovascular protective effects (improving blood circulation) |
| Storage Conditions | -20°C (long-term, sealed, dry, protected from light); 2-8°C (short-term storage ≤3 months) |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Notoginsenoside R1 exerts its protective effects through a complex interplay of signaling pathways. A core mechanism involves the inhibition of inflammatory responses and apoptosis. It significantly downregulates the NF-κB pathway, reducing the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6). It activates the PI3K/Akt and Nrf2/HO-1 pathways, promoting cell survival and enhancing antioxidant defenses. In cerebral and cardiac ischemia models, it improves microcirculation, reduces platelet aggregation, and protects endothelial cell function, thereby mitigating ischemic/reperfusion injury.
2.PRODUCT INDICATIONS
Notoginsenoside R1 is primarily indicated for use as a high-purity reference standard in the quality control and authentication of Panax notoginsengextracts and related products. Its research applications are vast, focusing on the development of therapeutic agents for cardiovascular diseases (e.g., atherosclerosis, myocardial infarction), cerebrovascular disorders (e.g., ischemic stroke), neuroprotection (e.g., against Alzheimer's disease), and anti-aging formulations. It is also studied for its potential to promote wound healing and mitigate diabetic complications.
3.CLINICAL EFFICACY OF PRODUCT
Robust preclinical studies provide strong evidence for the efficacy of Notoginsenoside R1. Animal models demonstrate its ability to reduce infarct size and improve neurological function after stroke, protect heart tissue from ischemic injury, and improve cognitive deficits in models of neurodegeneration. It shows potent anti-inflammatory and anti-apoptotic effects in various tissue injury models. These findings, supported by its status as a key bioactive of the clinically used herb Panax notoginseng, underscore its significant therapeutic potential and drive its use in advanced nutraceutical and pharmaceutical research.
- 4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
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Main Method: International Air Freight
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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
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