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Sanguinarine Chloride CAS NO.5578-73-4

Sanguinarine Chloride is a potent benzophenanthridine alkaloid derived from plants like Sanguinaria canadensisand Macleaya cordata. As a versatile natural active, it is widely used in research on antimicrobial, anti-inflammatory, and antitumor mechanisms, as well as a key functional ingredient in oral care products targeting plaque and gingivitis control. Its distinctive orange to red crystalline appearance and broad-spectrum bioactivity make it a high-value compound for pharmaceutical R&D and cosmetic applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Sanguinarine Chloride
CAS NO.	5578-73-4
Appearance	Yellow to orange-yellow crystalline powder
Molecular Formula	C₂₀H₁₄ClNO₄
Molecular Weight	367.78 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, methanol, DMSO; slightly soluble in ethanol
Endotoxin	≤10 EU/mg (or as per customer requirement)
Biological Activity	Antimicrobial, anti-inflammatory, anti-tumor, and anti-plaque activity
Storage Conditions	Store at 2-8°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The compound exerts its effects through multiple pathways: it potently inhibits bacterial Na+/K+-ATPase and disrupts cell membranes, leading to microbial death. In eukaryotic cells, it induces cell cycle arrest at the G1 phase and triggers apoptosis via ROS-mediated mitochondrial dysfunction and activation of caspase-3. Additionally, it modulates key signaling pathways including NF-κB and MAPK, reducing the expression of pro-inflammatory cytokines and contributing to its antitumor and immunoregulatory properties.

2.PRODUCT INDICATIONS

This product is indicated for research and development of oral hygiene formulations (toothpaste, mouthwash) aimed at reducing dental plaque and gingival inflammation. It is also utilized in preclinical studies focusing on anticancer drug discovery, anti-inflammatory agents, and broad-spectrum antimicrobial applications. The target audience includes R&D scientists in pharma and biotech, as well as formulators in the personal care industry seeking natural active ingredients with proven efficacy.

3.CLINICAL EFFICACY OF PRODUCT

Clinical studies, including trials on middle-aged females with photoaged facial skin, demonstrate that formulations containing Acetyl Hexapeptide-1 yield significant cosmetic improvements. Data confirms measurable reductions in wrinkle depth and volume, alongside enhanced skin firmness and a more even skin tone. In hair-related applications, consistent use has been shown to promote hair darkening and increase melanin content in follicles, validating its efficacy as a multi-functional active for achieving visible rejuvenation and pigmentation restoration.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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