Acetyl Hexapeptide-1 CAS NO.448944-47-6

Acetyl Hexapeptide-1, also known by trade names such as Melitane, is a biomimetic peptide derived from α-MSH (melanocyte-stimulating hormone). It is a versatile cosmetic active ingredient renowned for its dual-action benefits in both anti-aging skincare and hair pigmentation. This acetylated hexapeptide is designed to regulate melanin synthesis, making it a key ingredient in formulations targeting photoaged skin, uneven skin tone, and premature hair graying for a broad demographic of health-conscious consumers.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Acetyl Hexapeptide-1
CAS NO.	448944-47-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C43H59N13O7
Molecular Weight	870.01 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, PBS, or dilute acetic acid; partially soluble in DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Active as melanocortin receptor agonist; stimulates melanin synthesis & DNA repair mechanisms
Storage Conditions	Store at -20°C, protected from light and moisture; avoid freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a potent agonist of the melanocortin-1 receptor (MC1R), mimicking the activity of endogenous α-MSH. By binding to MC1R, it activates intracellular signaling pathways that upregulate tyrosinase activity and stimulate melanogenesis within melanocytes. This mechanism not only promotes the production and transfer of melanin to keratinocytes for natural pigmentation but also provides a photoprotective effect against UV-induced damage and oxidative stress, reinforcing the skin's intrinsic defense mechanisms.

2.PRODUCT INDICATIONS

Acetyl Hexapeptide-1 is primarily indicated for advanced skincare and hair care applications. It is extensively used in anti-aging serums, brightening creams, and sun care products to improve skin elasticity, reduce fine lines, and correct hyperpigmentation. In hair care, it is formulated into serums and conditioners aimed at reversing or preventing premature gray hair by restoring natural pigment. It is particularly suitable for middle-aged individuals experiencing early signs of photoaging or those seeking non-invasive solutions for hair color maintenance.

3.CLINICAL EFFICACY OF PRODUCT

Clinical studies, including trials on middle-aged females with photoaged facial skin, demonstrate that formulations containing Acetyl Hexapeptide-1 yield significant cosmetic improvements. Data confirms measurable reductions in wrinkle depth and volume, alongside enhanced skin firmness and a more even skin tone. In hair-related applications, consistent use has been shown to promote hair darkening and increase melanin content in follicles, validating its efficacy as a multi-functional active for achieving visible rejuvenation and pigmentation restoration.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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