N-methyl-N’-nitro-N-nitrosoguanidine CAS NO.52232-67-4/99294-94-7

N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is a highly potent monofunctional alkylating agent widely utilized in biomedical research as a chemical mutagen and carcinogen. This yellow crystalline solid is primarily employed to induce specific DNA lesions and establish experimental animal models of gastric adenocarcinoma. Due to its extreme reactivity and ability to generate point mutations efficiently, it serves as a critical tool for studying carcinogenesis mechanisms, DNA damage response pathways, and for screening potential chemopreventive agents. The product is intended for research use only under strict containment conditions, targeting scientists in oncology, toxicology, and genetics laboratories.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	N-methyl-N'-nitro-N-nitrosoguanidine
CAS NO.	52232-67-4/99294-94-7
Appearance	Yellow crystalline solid
Molecular Formula	C2H5N5O3
Molecular Weight	147.09 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in DMSO and ethanol; slightly soluble in water
Endotoxin	<0.1 EU/mg
Biological Activity	Potent alkylating agent and mutagen; induces DNA damage and gastric tumors
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

MNNG functions as a potent DNA alkylating agent that primarily methylates the O6 position of guanine and the O4 position of thymine, leading to the formation of mispairing lesions that evade standard DNA repair mechanisms. This results in a high frequency of GC to AT transition mutations, effectively inducing genetic alterations without causing significant helix distortion. The compound operates through an SN1 reaction mechanism, generating methyl diazonium ions that attack nucleophilic sites on DNA bases, thereby triggering a cascade of cellular responses including oxidative stress, inflammation, and apoptosis, which collectively drive mutagenesis and tumor initiation in experimental settings.

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2.PRODUCT INDICATIONS

This product is specifically indicated for use in preclinical research to establish chemically-induced carcinogenesis models, particularly for gastric cancer studies in rodents. It is also employed in bacterial and mammalian cell mutagenesis assays to assess genetic toxicity and DNA repair capacity. Researchers utilize MNNG to investigate the efficacy of anti-cancer drugs and natural compounds in preventing or delaying tumor development, making it a staple in pharmacology and toxicology screening. The product is strictly designated for laboratory applications by trained professionals in controlled environments, and it is not for diagnostic, therapeutic, or human use under any circumstances.

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3.CLINICAL EFFICACY OF PRODUCT

In the research context, MNNG demonstrates high efficacy in reliably generating tumors with pathological features that closely mimic human adenocarcinomas, particularly in the stomach mucosa of animal models. Studies have shown that controlled administration leads to well-differentiated adenocarcinomas, enabling detailed investigation of cancer progression and metastasis. Its effectiveness as a mutagen is evidenced by its ability to produce consistent mutation spectra in vitro, facilitating the study of gene function and the identification of molecular targets for cancer therapy. The product's reliability in inducing these biological endpoints underpins its value in validating experimental models for translational cancer research.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

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We can also customize packaging according to customer needs.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags:MNNG, alkylating agent, chemical mutagen, carcinogen, DNA damage, gastric cancer model, mutagenesis, nitrosoguanidine, research chemical, toxicology, oncology resea, Supplier, Manufacturer, Bulk order, Pharmaceutical.

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