Larazotide CAS NO.258818-34-7

Larazotide is a synthetic octapeptide zonulin receptor antagonist, structurally derived from the zonula occludens toxin (Zot), designed to regulate intestinal epithelial tight junctions. It functions as a first-in-class intestinal barrier protector, specifically targeting the paracellular pathway to reduce gut permeability. This research-grade peptide is primarily utilized in preclinical studies investigating autoimmune and inflammatory gastrointestinal conditions, offering a targeted approach to managing conditions associated with "leaky gut" pathophysiology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Larazotide
CAS NO.	258818-34-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C32H55N9O10
Molecular Weight	725.83 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water and certain organic solvents such as DMSO at appropriate concentrations
Endotoxin	< 1.0 EU/mg
Biological Activity	Larazotide is a synthetic peptide that acts as an intestinal permeability modulator. It has been shown to inhibit the paracellular pathway in the intestinal epithelium, reducing the passage of harmful substances from the gut lumen into the underlying tissues. In preclinical and clinical studies, it has demonstrated efficacy in improving symptoms associated with various gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel diseases, by restoring normal intestinal barrier function.
Storage Conditions	Store at – 20°C in a dry and dark place. Protect from light, moisture, and extreme temperatures to maintain product stability.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Larazotide acts as a potent zonulin receptor antagonist, competitively blocking the binding of endogenous zonulin to its receptor on intestinal epithelial cells. By inhibiting this interaction, it prevents the disassembly of tight junction proteins such as occludin and ZO-1, thereby maintaining the integrity of the intestinal barrier. This mechanism effectively reduces paracellular permeability, limiting the translocation of pro-inflammatory antigens and gluten peptides into the lamina propria, which is critical in preventing immune activation in sensitive individuals.

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2.PRODUCT INDICATIONS

This product is indicated for research applications focused on celiac disease, autoimmune enteropathies, and conditions characterized by increased intestinal permeability. It serves as a key tool for investigating the role of the zonulin pathway in Type 1 diabetes, inflammatory bowel disease (IBD), and systemic inflammatory responses. Researchers utilize Larazotide to explore adjuvant therapies that target barrier function restoration in patients with persistent symptoms despite dietary modifications.

3.CLINICAL EFFICACY OF PRODUCT

In clinical research settings, Larazotide has demonstrated efficacy in reducing gastrointestinal symptom severity and improving quality-of-life scores in subjects with celiac disease on a gluten-free diet. Studies have shown it can significantly decrease intestinal permeability markers and attenuate gluten-induced immune responses. While earlier phase trials confirmed its ability to mitigate abdominal pain and bloating, its development highlights its potential as a non-dietary intervention for barrier dysfunction-related disorders.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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