isoformononetin CAS NO.486-63-5

Isoformononetin is a naturally occurring methoxylated isoflavone, structurally analogous to daidzein and formononetin, primarily sourced from legumes and herbal extracts. As a potent phytoestrogen, it is widely utilized in dietary supplements targeting women's health, particularly for managing menopausal symptoms and bone density support. It also serves as a critical reference standard and active ingredient in pharmaceutical research focused on neuroinflammation, metabolic disorders, and immunomodulation due to its favorable bioavailability and dual estrogenic/anti-inflammatory properties.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	isoformononetin
CAS NO.	486-63-5
Appearance	Off-white to light yellow crystalline powder
Molecular Formula	C16H12O4
Molecular Weight	268.26 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, methanol, ethanol; slightly soluble in water
Endotoxin	≤ 5 EU/mg (for pharmaceutical grade)
Biological Activity	Estrogenic activity, anti-inflammatory, antioxidant, neuroprotective
Storage Conditions	Store at 2–8°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Isoformononetin exerts its effects through multiple pathways, functioning as a selective estrogen receptor modulator (SERM) by binding to estrogen receptors (ERα/ERβ) to mimic or modulate endogenous estrogenic activity. It significantly inhibits the NLRP3/ASC/IL-1β inflammasome axis, reducing the production of pro-inflammatory cytokines such as IL-1β and IL-18, which underlies its neuroprotective and anti-arthritic effects. Additionally, it promotes osteoblast differentiation and bone formation via the MEK/ERK and Akt signaling pathways while suppressing osteoclastogenesis, thereby directly countering bone loss mechanisms.

2.PRODUCT INDICATIONS

This compound is indicated for the formulation of nutraceuticals and functional foods aimed at postmenopausal women, focusing on alleviating hot flashes, improving bone mineral density, and supporting overall hormonal balance. It is also applied in research-grade supplements for joint health and inflammatory conditions like osteoporosis and neuroinflammatory diseases (e.g., diabetic neuropathy). Furthermore, it is extensively used as a high-purity analytical standard in quality control laboratories for the quantification of isoflavones in botanical extracts, red clover, and soy-based products.

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3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Isoformononetin effectively preserves bone mass in estrogen-deficient models by inhibiting Th17 cell differentiation and B-cell lymphopoiesis, leading to enhanced osteogenesis and reduced bone resorption markers. In neurological models, it shows significant protection against streptozotocin-induced neuroinflammation by downregulating NLRP3 inflammasome activation, resulting in improved cognitive function and reduced neuronal damage. Clinical data from phytoestrogen-rich supplement trials suggest its potential in safely reducing menopausal symptom severity and improving lipid profiles with minimal side effects compared to conventional hormone therapy.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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