ACTH (11-24) CAS NO.4237-93-8

ACTH (11-24) is a bioactive C-terminal fragment of Adrenocorticotropic Hormone, widely used in neuroscience and endocrinology research to study stress responses, adrenal function, and melanocortin receptor signaling. Unlike the full-length ACTH, this fragment exhibits unique receptor-binding properties, making it a valuable tool for investigating HPA axis regulation, neuroimmunology, and cognitive function without inducing full steroidogenesis. Its high solubility and stability in aqueous solutions facilitate easy handling in both in vitro and in vivo experimental models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	ACTH (11-24) (Adrenocorticotropic Hormone Fragment 11-24)
CAS NO.	4237-93-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₇₇H₁₃₄N₂₄O₁₆
Molecular Weight	1652.08g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water and DMSO; aqueous solutions are stable at neutral pH
Endotoxin	≤ 0.1 EU/mg (for research-grade materials; subject to batch-specific Certificate of Analysis)
Biological Activity	Melanocortin 2 receptor (MC2R) ligand; acts primarily as a partial agonist/antagonist modulating cortisol release and HPA axis signaling
Storage Conditions	Lyophilized powder: Store at -20°C, protected from light and moisture; stable for years. Solutions: Store at -20°C for short-term use; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts primarily as a ligand for melanocortin receptors (especially MC2R), where it can function as a partial agonist or antagonist depending on the context. It binds to adrenal cortex receptors and modulates adenylate cyclase activity, influencing intracellular cAMP levels and subsequent cortisol production. In the central nervous system, it interacts with other melanocortin receptor subtypes to affect neurotransmitter release, neuroprotection, and behavioral responses, providing a nuanced tool for dissecting ACTH signaling pathways.

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2.PRODUCT INDICATIONS

ACTH (11-24) is indicated for research into adrenal gland physiology, stress-related disorders, and neuroinflammatory conditions. It is used to model HPA axis dysregulation, study mechanisms of Cushing's syndrome, and explore novel therapeutics for mood disorders and cognitive decline. Researchers also employ it in immunology studies to understand the crosstalk between stress hormones and immune cell function, as well as in drug discovery screens for melanocortin receptor-targeting compounds.

3.CLINICAL EFFICACY OF PRODUCT

In preclinical models, ACTH (11-24) has demonstrated efficacy in modulating cortisol release, reducing edema in inflammation studies, and improving memory retention in cognitive tests. It shows partial biological activity compared to full-length ACTH, making it ideal for competitive inhibition experiments and receptor occupancy studies. While not a therapeutic agent itself, its efficacy profile supports its use as a reference standard for developing treatments targeting the melanocortin system and stress-related pathologies.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: ACTH1124 #MelanocortinReceptor #HPAAxis #AdrenalResearch #StressPeptide #Neuroimmunology #ResearchPeptide #CorticotropinFragment

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