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Gambogic acid CAS 2752-65-0

Gambogic acid is a naturally derived xanthonoid compound extracted from Garcinia hanburyi resin, recognized for its potent anti-tumor and anti-inflammatory bioactivities. As a high-purity active ingredient, it is primarily utilized in pharmaceutical research and preclinical development for cancer therapeutics, offering significant potential in inducing apoptosis and inhibiting tumor progression across various cell lines.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gambogic acid
CAS NO.	2752-65-0
Appearance	Yellow to orange-yellow amorphous powder
Molecular Formula	C38H44O8
Molecular Weight	628.75g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, ethanol; poorly soluble in water
Endotoxin	≤ 10 EU/mg (or as per customer requirement)
Biological Activity	Potent anti-tumor, anti-inflammatory, and apoptosis-inducing activity
Storage Conditions	Store at 2–8°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Gambogic acid exerts its anti-tumor effects through multiple pathways, primarily by binding to the transferrin receptor and heat shock protein 90 (Hsp90), thereby disrupting oncogenic signaling cascades such as PI3K/Akt and NF-κB. It induces apoptosis and non-apoptotic cell death (paraptosis) via proteasomal inhibition and ER stress, while also suppressing tumor angiogenesis and metastasis by modulating EMT-related markers like E-cadherin and vimentin.

2.PRODUCT INDICATIONS

This compound is indicated for research and development in solid tumor therapies, including lung, breast, liver, and pancreatic cancers, as well as hematologic malignancies. It is particularly relevant for researchers focusing on combination chemotherapy, drug resistance reversal, and nano-drug delivery systems aimed at improving the bioavailability and targeting efficacy of anti-cancer agents.

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3.CLINICAL EFFICACY OF PRODUCT

Clinical evaluations demonstrate that topical application of Tripeptide-29 at effective concentrations leads to a statistically significant reduction in wrinkle depth and volume around the eye area after 4-8 weeks of use. Studies also confirm measurable improvements in skin elasticity and firmness, supported by a marked increase in collagen density within the extracellular matrix, validating its role as a potent anti-aging active.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544