Adrenomedullin (human) CAS NO.148498-78-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Adrenomedullin (human) |
| CAS NO. | 148498-78-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₂₆₄H₄₀₆N₈₀O₇₇S₃ |
| Molecular Weight | 6028.82g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water and dilute acids; partially soluble in DMSO; insoluble in non-polar solvents |
| Endotoxin | ≤ 0.1 EU/mg (for research-grade materials; subject to batch-specific Certificate of Analysis) |
| Biological Activity | Potent vasodilatory peptide; activates calcitonin gene-related peptide (CGRP) receptors; modulates vascular tone, blood pressure, and immune response |
| Storage Conditions | Lyophilized powder: Store at -20°C in a dry, dark place; stable for 24–36 months. Reconstituted solutions: Store at -20°C, protected from light, and use within 1–2 weeks; avoid freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Adrenomedullin (human) exerts its effects primarily through binding to and activating calcitonin gene-related peptide (CGRP) receptors, which are G-protein-coupled receptors coupled to adenylate cyclase, leading to elevated intracellular cAMP levels. This activation triggers downstream signaling cascades that result in smooth muscle relaxation, vasodilation, and increased capillary permeability. Beyond vascular effects, it modulates immune cell function, inhibits apoptosis in cardiomyocytes, and regulates fluid homeostasis by promoting sodium excretion. Its ability to cross-talk with nitric oxide synthase pathways enhances its role in maintaining cardiovascular equilibrium and protecting against ischemic injury.
2.PRODUCT INDICATIONS
Adrenomedullin (human) is indicated for research applications involving cardiovascular biology, hypertension, heart failure, stroke, pulmonary hypertension, and renal physiology. It serves as a key reagent for studying the pathophysiology of endothelial dysfunction, angiogenesis, and neurovascular coupling. Researchers developing novel vasodilators, antihypertensive agents, or cardioprotective therapies rely on this peptide for mechanism-of-action studies, receptor-ligand binding assays, and in vivo pharmacokinetic modeling. Its relevance extends to oncology research, where it influences tumor microcirculation and metastasis through vascular remodeling and immune modulation.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Adrenomedullin #HumanPeptide #CardiovascularResearch #Vasodilator #CGRPReceptor #PeptideTherapeutics #ResearchGrade #MolecularBiology #Pharmacology #BiotechSupply #EndothelialFunction #HeartFailure #VascularTone #RecombinantPeptide #ScientificResearch
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
