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Plecanatide CAS NO.467426-54-6

Plecanatide is a synthetic peptide analog of uroguanylin, designed as a potent activator of the intestinal guanylate cyclase-C (GC-C) receptor. It is engineered for high specificity and affinity toward GC-C, which is predominantly expressed in the intestinal epithelium. Upon binding, it stimulates intracellular cGMP production, triggering chloride and bicarbonate secretion into the intestinal lumen while reducing sodium absorption, thereby promoting fluid secretion and accelerating intestinal transit. This mechanism makes it a promising therapeutic agent for the management of chronic constipation and irritable bowel syndrome with constipation (IBS-C). The lyophilized powder form ensures long-term stability under controlled storage, making it suitable for both preclinical research and clinical development pipelines. Its high purity and low endotoxin levels support its use in sensitive biological assays and in vitro models of gastrointestinal physiology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Plecanatide
CAS NO.	467426-54-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₅H₁₀₄N₁₈O₂₆S₄
Molecular Weight	1681.88 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water and dilute acids; partially soluble in DMSO; insoluble in non-polar solvents
Endotoxin	≤ 50 EU/mg (for cell culture and in vitro use; may differ by batch)
Biological Activity	Potent guanylate cyclase-C (GC-C) agonist; stimulates intestinal fluid secretion and accelerates transit; exhibits anti-constipation effects
Storage Conditions	Lyophilized powder: Store at 2–8°C in a dry, dark place; stable for 24–36 months. Reconstituted solutions: Store at -20°C, protected from light, and use within 1–2 weeks; avoid freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Plecanatide functions as a selective agonist of the guanylate cyclase-C (GC-C) receptor located on the luminal surface of intestinal epithelial cells. Binding activates intracellular cGMP signaling, which drives chloride and bicarbonate ion secretion into the gut lumen while inhibiting sodium absorption, resulting in osmotic water influx and accelerated intestinal transit. This mechanism directly addresses the pathophysiology of constipation by enhancing motility and hydration of stool, distinguishing it from traditional laxatives that primarily stimulate nerves or muscles.

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2.PRODUCT INDICATIONS

Plecanatide is indicated for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It is also studied for potential use in other functional gastrointestinal disorders involving impaired motility or secretion. Suitable for patients unresponsive to conventional laxatives or seeking targeted, receptor-mediated therapy with fewer systemic side effects. Ideal for clinical trials, formulation development, and mechanistic studies in GI pharmacology.

3.CLINICAL EFFICACY OF PRODUCT

Clinical trials demonstrate that Plecanatide significantly increases the frequency of spontaneous bowel movements (SBMs) and improves stool consistency compared to placebo in patients with CIC and IBS-C. It also reduces straining and abdominal discomfort, with a favorable safety profile including minimal systemic absorption and low risk of electrolyte imbalance. Efficacy is consistent across multiple Phase II and III studies, supporting its regulatory approval and adoption in gastroenterology care pathways.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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