Albiglutide CAS NO.782500-75-8

Albiglutide (marketed under brand names Tanzeum and Eperzan) is a long-acting, once-weekly injectable GLP-1 receptor agonist developed for adults with type 2 diabetes. It is designed as an adjunct to diet and exercise to improve glycemic control, offering a convenient dosing schedule for patients who struggle with daily medication adherence. The product is typically used when other antidiabetic agents like metformin do not provide adequate control, and it can be combined with various oral therapies or basal insulin, though it is not indicated for type 1 diabetes or diabetic ketoacidosis.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Albiglutide
CAS NO.	782500-75-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C148H223N39O46
Molecular Weight	3284.6 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water; reconstitute with provided diluent before injection
Endotoxin	< 5 EU/mg
Biological Activity	Potent GLP-1 receptor agonist; enhances insulin secretion, suppresses glucagon, slows gastric emptying
Storage Conditions	Store at 2–8°C; protect from light; do not freeze
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Albiglutide works by mimicking the body’s natural incretin hormone GLP-1, binding to and activating GLP-1 receptors to stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner—meaning it primarily acts when blood sugar is high, reducing the risk of hypoglycemia. Additionally, it suppresses glucagon secretion, slows gastric emptying to moderate postprandial glucose spikes, and promotes satiety, which can contribute to reduced food intake. Its unique design as a fusion protein with human albumin makes it resistant to degradation by the DPP-4 enzyme, granting it a prolonged half-life suitable for once-weekly subcutaneous administration.

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2.PRODUCT INDICATIONS

Albiglutide is indicated as an adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus, either as monotherapy or in combination with other glucose-lowering medications such as metformin, sulfonylureas, or basal insulin. It is particularly relevant for patients seeking a less frequent dosing regimen to simplify their treatment schedule. However, it is not recommended as a first-line therapy for patients inadequately controlled by diet and exercise alone, and it should not be used in patients with a history of pancreatitis, type 1 diabetes, or for the treatment of diabetic ketoacidosis.

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3.CLINICAL EFFICACY OF PRODUCT

Clinical trials from the HARMONY program demonstrated that Albiglutide provides significant and sustained reductions in HbA1c (placebo-corrected reductions of approximately -0.8% to -1.0%) and fasting plasma glucose over periods of up to three years. While it effectively improves glycemic parameters, its effect on body weight is generally modest compared to some other GLP-1 receptor agonists. The safety profile is characterized by a low risk of hypoglycemia when used alone, though the risk increases when combined with sulfonylureas or insulin; common side effects include gastrointestinal symptoms such as nausea and diarrhea, which are typically mild and transient.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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