ACTH(1-39) CAS NO.12279-41-3

ACTH (1-39), also known as Adrenocorticotropic Hormone, is a peptide hormone derived from the anterior pituitary gland, playing a critical role in regulating adrenal function and systemic homeostasis. This high-purity lyophilized powder is ideal for researchers studying endocrine disorders, stress physiology, and metabolic regulation. Its potent bioactivity supports studies on cortisol secretion, inflammation modulation, and immune response. Suitable for in vitro and in vivo preclinical models, it offers consistent performance with low endotoxin levels for cell culture applications. Designed for laboratory use only, ACTH (1-39) is stored under recommended conditions to maintain stability and potency over extended periods.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	ACTH (1-39) (Adrenocorticotropic Hormone)
CAS NO.	12279-41-3
Appearance	White to off-white crystalline powder
Molecular Formula	C₂₀₇H₃₀₈N₅₆O₅₈S
Molecular Weight	4541.55 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water and dilute acids; partially soluble in DMSO; insoluble in non-polar solvents
Endotoxin	≤ 50 EU/mg (for cell culture and in vitro use; may differ by batch)
Biological Activity	Stimulates adrenal cortex to secrete cortisol and other glucocorticoids; regulates stress response, metabolism, and immune function
Storage Conditions	Lyophilized powder: Store at 2–8°C in a dry, dark place; stable for 24–36 months. Reconstituted solutions: Store at -20°C, protected from light, and use within 1–2 weeks; avoid freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

ACTH (1-39) binds specifically to melanocortin type 2 receptors (MC2R) on adrenal cortical cells, triggering intracellular signaling cascades that promote cholesterol mobilization and conversion into pregnenolone—the rate-limiting step in cortisol biosynthesis. This action not only elevates circulating glucocorticoid levels but also modulates inflammatory pathways and immune cell activity, positioning ACTH as a key regulator of both metabolic and immune homeostasis.

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2.PRODUCT INDICATIONS

ACTH (1-39) is indicated for research use in preclinical models investigating adrenal insufficiency, Cushing’s syndrome, autoimmune diseases, and stress-related metabolic disorders. It serves as a valuable reagent for exploring hormone replacement therapies, evaluating adrenal gland function, and understanding the interplay between neuroendocrine and immune systems in both animal and human-derived cell systems.

3.CLINICAL EFFICACY OF PRODUCT

While primarily used in research settings, ACTH (1-39) has demonstrated efficacy in clinical diagnostics and therapeutic contexts for diagnosing adrenal disorders such as Addison’s disease and congenital adrenal hyperplasia. In therapeutic applications, synthetic ACTH analogs have shown efficacy in treating infantile spasms and certain inflammatory conditions. Its ability to precisely modulate cortisol output makes it a cornerstone in both diagnostic testing and targeted therapeutic strategies for endocrine and neurological conditions.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157