Dehydrocostuslactone CAS NO.477-43-0

Dehydrocostuslactone (DHL) is a natural sesquiterpene lactone primarily extracted from the medicinal plant Saussurea costus(Aucklandia lappa), commonly known as "Mu Xiang" in traditional medicine. It is a key bioactive compound valued for its dual anti-inflammatory and anti-tumor properties, making it a critical reference standard and raw material for pharmaceutical R&D, particularly in inflammation-related disease models and natural product synthesis.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dehydrocostuslactone
CAS NO.	1477-43-0
Appearance	White to off-white crystalline powder
Molecular Formula	C₁₅H₁₈O₂
Molecular Weight	230.30 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, methanol, ethanol, acetone; sparingly soluble in water; insoluble in n-hexane
Endotoxin	≤ 5 EU/mg (for cell culture grade)
Biological Activity	Inhibits NF-κB signaling, suppresses inflammatory cytokine production (TNF-α, IL-6, COX-2), induces apoptosis in cancer cells, modulates immune response, exhibits antimicrobial and anti-parasitic effects
Storage Conditions	Store at -20°C, protected from light and moisture; stable for 24 months under recommended conditions
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Dehydrocostuslactone exerts its effects primarily by inhibiting the NF-κB signaling pathway. It directly targets IKKβ, preventing the phosphorylation and degradation of IκBα, which blocks the nuclear translocation of NF-κB subunits (p50/p65) and their binding to DNA promoters of pro-inflammatory genes like COX-2 and iNOS. This action reduces the production of inflammatory mediators (TNF-α, IL-6) and, in cancer cells, induces mitochondrial-dependent apoptosis and cell cycle arrest, thereby suppressing proliferation and invasion.

2.PRODUCT INDICATIONS

This compound is indicated for research in inflammatory diseases such as ulcerative colitis, osteoarthritis, and acute lung injury, where NF-κB-driven inflammation is a key pathology. It is also used in oncology research for studying apoptosis induction in various cancer cell lines (e.g., leukemia, prostate cancer, glioblastoma) and in pharmacological studies exploring its gastroprotective and hepatoprotective effects, targeting researchers in immunology, cancer biology, and natural product development.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Dehydrocostuslactone significantly ameliorates disease severity in animal models; for instance, it reduces colonic inflammation and pathological scores in DSS-induced colitis models and inhibits tumor growth in xenograft models without notable toxicity. Its efficacy is attributed to high bioavailability and the ability to cross biological barriers, showing dose-dependent inhibition of both inflammatory markers and cancer cell viability in vitro and in vivo..

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

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Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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