3-Deoxysappanchalcone CAS NO.112408-67-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | 3-Deoxysappanchalcone |
| CAS NO. | 112408-67-0 |
| Appearance | Yellowish to orange crystalline powder |
| Molecular Formula | C16H14O4 |
| Molecular Weight | 270.30 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol, and ethanol; slightly soluble in water |
| Endotoxin | <0.001 EU/mg |
| Biological Activity | Inhibits kinases (e.g., MET, EGFR, AKT, mTOR), anti-inflammatory, antiviral |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
3-Deoxysappanchalcone exerts its effects by directly targeting and inhibiting multiple key cellular kinases and viral proteins, including MET, EGFR, AKT, mTOR, p38 MAPK, JNK, thrombin, FXa, and influenza virus neuraminidase. By disrupting these signaling nodes, it induces cell cycle arrest (notably at the G2/M phase), promotes reactive oxygen species (ROS) generation, and triggers mitochondrial-mediated apoptosis in cancer cells. Additionally, its anti-inflammatory action is mediated through the activation of the AKT/mTOR pathway, leading to the upregulation of heme oxygenase-1 (HO-1) expression, which provides a protective effect against oxidative and inflammatory stress.
2.PRODUCT INDICATIONS
This product is indicated for scientific research applications focused on oncology, virology, and immunology. It is particularly relevant for studies involving gefitinib-resistant non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma, colon cancer, and skin cancer models. Beyond oncology, it serves as a useful compound for investigating anti-thrombotic therapies due to its anticoagulant properties, as well as for exploring novel treatments against influenza virus infections (such as H3N2) and various inflammatory or allergic conditions driven by macrophage and endothelial cell activation.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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