Apelin-36 (human) CAS NO.252642-12-9

Apelin-36 (human) is the endogenous full-length ligand for the G protein-coupled APJ receptor, widely utilized in cardiovascular and metabolic research. This high-purity synthetic peptide is characterized by its potent inotropic and vasodilatory effects, making it a critical tool for studying heart function, glucose homeostasis, and energy metabolism in preclinical models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Apelin-36 (human)
CAS NO.	252642-12-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₈₄H₂₉₇N₆₉O₄₃S₁
Molecular Weight	4295.9 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acidic solutions; insoluble or poorly soluble in neutral buffers
Endotoxin	≤1 EU/mg (LAL test)
Biological Activity	Stimulates cardiac contractility, induces vasodilation, enhances insulin sensitivity, modulates glucose uptake in adipose and skeletal muscle tissues
Storage Conditions	Store at -20°C, protected from light; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Apelin-36 binds to the APJ receptor with high affinity, activating G protein signaling pathways that stimulate cardiac contractility and induce nitric oxide-mediated vasodilation. It also modulates the PI3K/Akt and MAPK pathways, which are crucial for cell survival, anti-apoptotic effects, and metabolic regulation, including insulin sensitivity and glucose uptake.

2.PRODUCT INDICATIONS

This peptide is indicated for in vitro and in vivo research focused on cardiovascular diseases (such as heart failure and hypertension), metabolic disorders (including diabetes and obesity), and neuroprotection studies. It is suitable for researchers investigating ischemia-reperfusion injury, vascular function, and the interplay between adipose tissue and energy balance.

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3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies demonstrate that Apelin-36 reduces infarct size in myocardial ischemia models, improves cardiac output, and lowers blood glucose levels in diabetic animals. It shows promise in protecting against organ injury by reducing oxidative stress and inflammation, highlighting its potential as a lead compound for therapeutic development in cardiometabolic syndromes.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Apelin36 #APJReceptor #CardiovascularResearch #MetabolicSyndrome #ResearchPeptide #HeartFailure #DiabetesResearch #GPCRagonist

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