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Amyloid β-Protein (1-12) CAS NO.142047-91-4

Amyloid β-Protein (1-12) is a synthetic N-terminal fragment of the amyloid-β peptide, encompassing the first 12 amino acids. This truncated peptide is a crucial research tool for studying the early stages of Aβ aggregation, fibrillization, and the structural basis of amyloid formation. It is widely used in neuroscience and biochemistry to investigate the pathogenesis of Alzheimer's disease without the high aggregation propensity of the full-length Aβ42, making it ideal for mechanistic studies and screening of anti-aggregation compounds.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Amyloid β-Protein (1-12)
CAS NO.	142047-91-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₁H₈₅N₁₇O₂₃
Molecular Weight	1424.4 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, DMSO, or 0.1 M HCl solution
Endotoxin	≤1 EU/mg (LAL test)
Biological Activity	Used as a research tool for Aβ aggregation, metal ion binding, and early Alzheimer’s pathology studies
Storage Conditions	Lyophilized powder stored at 2–8°C; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide contains the hydrophilic N-terminal domain of Aβ, which plays a role in initial protein-protein interactions and metal ion binding (e.g., Cu²⁺, Zn²⁺). While it lacks the hydrophobic core required for full fibril formation, it can undergo oligomerization and influence the aggregation kinetics of longer Aβ species. Its primary research utility lies in its ability to bind antibodies and receptors, serving as a model for epitope mapping, immunoassay development, and studying the molecular interactions that precede plaque deposition in Alzheimer's pathology.

2.PRODUCT INDICATIONS

This product is indicated for research applications in Alzheimer's disease, including antibody characterization, ELISA development, and structural biology studies. It is also used in screening platforms for inhibitors of Aβ aggregation and metal chelators targeting amyloid-related toxicity. Neuroscientists, immunologists, and pharmaceutical R&D teams utilize it to explore diagnostic biomarkers and therapeutic strategies for neurodegenerative disorders.

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3.CLINICAL EFFICACY OF PRODUCT

In preclinical research, Aβ (1-12) is valued for its use in generating specific antibodies for PET imaging and immunotherapy, such as in the development of amyloid-targeting vaccines. Studies show that antibodies raised against this fragment can recognize amyloid plaques and soluble oligomers, supporting its role in diagnostic and therapeutic research aimed at detecting and mitigating early amyloid pathology in Alzheimer's models.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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