Bradykinin [Hyp3] CAS NO.37642-65-2

Bradykinin [Hyp³], also known as [Hyp³]-Bradykinin, is a bioactive analog of the endogenous nonapeptide bradykinin, where the third amino acid proline is substituted with hydroxyproline (Hyp). Naturally occurring and widely used as a high-purity research tool, this peptide serves as a potent agonist for the B₂ bradykinin receptor. It is primarily utilized in cardiovascular, inflammation, and pain research to study vascular tone regulation, inflammatory mediator release, and nociceptive signaling pathways with receptor specificity.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Bradykinin [Hyp3]
CAS NO.	37642-65-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C₃₀H₇₂N₁₅O₁₀
Molecular Weight	720.0g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water or 0.1% TFA in water; insoluble in neutral buffers without acid
Endotoxin	≤ 1 EU/mg (standard for research grade)
Biological Activity	Potent B₂ receptor agonist; induces vasodilation, increased vascular permeability, and pain respons
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a selective agonist for the G protein-coupled B₂ bradykinin receptor. Upon binding, it activates the Gq/11 signaling pathway, stimulating phospholipase C (PLC) to hydrolyze PIP₂ into IP₃ and diacylglycerol (DAG). This leads to a rapid increase in intracellular calcium levels and activation of protein kinase C (PKC). The downstream cascade stimulates endothelial nitric oxide synthase (eNOS) and cyclooxygenase (COX), resulting in the release of nitric oxide (NO) and prostaglandins, which collectively mediate endothelium-dependent vasodilation, increased vascular permeability, and pain sensitization.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research applications focused on the kallikrein-kinin system. It is employed to investigate physiological and pathological processes in hypertension, septic shock, angioedema, asthma, and neurogenic inflammation. Researchers use it in vascular reactivity assays, receptor binding studies, and to evaluate the efficacy of novel anti-inflammatory or analgesic compounds targeting the bradykinin pathway, making it essential for pharmacologists and immunologists.

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3.CLINICAL EFFICACY OF PRODUCT

In preclinical models, Bradykinin [Hyp³] demonstrates efficacy equivalent to native bradykinin in inducing hypotension, reducing peripheral vascular resistance, and promoting plasma extravasation. Studies confirm its ability to stimulate inositol phosphate production in human fibroblasts and contract uterine tissue, validating its role as a reliable reference agonist. While not used therapeutically, its consistent and potent bioactivity supports its utility as a standard for developing diagnostic assays and screening B₂ receptor modulators for clinical translation.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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