Lys-(Des-Arg9,Leu8)-Bradykinin CAS NO.71800-37-8

Lys-(Des-Arg⁹,Leu⁸)-Bradykinin is a synthetic 8-amino acid bradykinin analog designed as a selective agonist for the bradykinin B₁ receptor. It features a lysine extension at the N-terminus, replacement of the 8th proline with leucine, and deletion of the C-terminal arginine. These modifications shift its receptor selectivity from the constitutive B₂ receptor to the inducible B₁ receptor, making it a key research tool for studying the role of B₁R in chronic inflammation, neuropathic pain, and cardiovascular pathologies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Lys-(Des-Arg9,Leu8)-Bradykinin
CAS NO.	71800-37-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₄₇H₇₅N₁₃O₁₁
Molecular Weight	1038.8g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water or 0.1% acetic acid; soluble in dilute acids or buffer systems
Endotoxin	< 1 EU/mg (as per standard endotoxin test)
Biological Activity	Selective agonist for B₁ bradykinin receptor; activates B₁R signaling pathways
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide acts as a potent and selective agonist for the G protein-coupled bradykinin B₁ receptor. Upon binding, it activates Gq/11-mediated signaling, leading to phospholipase C activation, IP₃ production, and intracellular calcium mobilization. This cascade stimulates MAP kinase pathways (ERK1/2, p38) and NF-κB, promoting the expression of pro-inflammatory cytokines (IL-1β, TNF-α) and adhesion molecules. The B₁ receptor is typically absent in healthy tissues but upregulated during inflammation, making this analog particularly useful for studying pathological conditions involving sustained kinin signaling.

2.PRODUCT INDICATIONS

This product is indicated for research focusing on chronic inflammatory diseases, neuropathic pain, sepsis, and diabetic complications where B₁ receptor expression is elevated. It is used to investigate the role of B₁R in persistent hyperalgesia, vascular remodeling, and endothelial dysfunction. Researchers employ it in cell-based assays, isolated tissue preparations, and animal models of chronic inflammation to screen B₁ receptor antagonists and to validate the therapeutic potential of targeting this receptor in conditions like rheumatoid arthritis and neuroinflammation.

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3.CLINICAL EFFICACY OF PRODUCT

In preclinical models, Lys-(Des-Arg⁹,Leu⁸)-Bradykinin demonstrates high efficacy in inducing B₁ receptor-mediated hyperalgesia, vascular leakage, and cytokine release. Studies show it exacerbates inflammatory responses in models of adjuvant-induced arthritis and diabetic neuropathy, while B₁ antagonists effectively block its effects. Although not used clinically, its selective agonist profile has been instrumental in validating B₁R as a therapeutic target, supporting the development of clinical-stage B₁ antagonists for chronic pain and inflammatory disorders.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: B1ReceptorAgonist #BradykininAnalog #KininResearch #ChronicInflammation #NeuropathicPain #B1Ragonist #InflammationModel #PeptideResearch

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