Bradykinin (2-7) CAS NO.23828-06-0

Bradykinin (2-7) is a bioactive hexapeptide fragment derived from the proteolytic cleavage of endogenous bradykinin, retaining key residues for receptor interaction. This research-grade peptide is characterized by its high purity and stability, making it a valuable tool for scientists studying the kallikrein-kinin system (KKS) and the functional roles of bradykinin metabolites. It is primarily utilized in biochemical and pharmacological research to investigate non-classical kinin signaling pathways, serving as a reference standard in metabolic studies and receptor characterization assays.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Bradykinin (2-7)
CAS NO.	23828-06-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₉H₄₀N₆O₈
Molecular Weight	612.67g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water or 0.1% TFA in water; soluble in dilute acetic acid
Endotoxin	< 1 EU/mg (or as specified per batch)
Biological Activity	Potent modulator of vascular tone and endothelial function; activates alternative kinin pathways
Storage Conditions	Store at -20°C, protected from light and moisture; avoid freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Unlike full-length bradykinin, which primarily activates B₂ receptors, Bradykinin (2-7) exhibits a distinct mechanism that is often independent of the classical B₁ and B₂ kinin receptors. Research suggests it may modulate vascular tone and inflammation through alternative pathways, potentially involving nitric oxide (NO) release and calcium signaling in endothelial and smooth muscle cells. Its activity provides insights into the physiological relevance of bradykinin degradation products, highlighting its role in studying receptor-independent effects of kinin fragments in experimental models.

2.PRODUCT INDICATIONS

This peptide is indicated for in vitro and ex vivo research applications focused on cardiovascular physiology, inflammation, and kinin metabolism. It is used as a probe to differentiate between canonical receptor-mediated responses and fragment-specific biological activities in vascular permeability assays, smooth muscle contraction studies, and cell signaling experiments. Researchers in academic and pharmaceutical settings employ it to elucidate the pathophysiological roles of kinin fragments in conditions like hypertension, sepsis, and tissue injury.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental settings, Bradykinin (2-7) demonstrates efficacy in eliciting vasoactive and pro-inflammatory responses, albeit with a different potency profile compared to the parent bradykinin molecule. Studies report its ability to induce vasodilation and moderate hypotensive effects in certain vascular preparations, supporting its utility as a biologically active metabolite in preclinical research. While not a therapeutic agent, its consistent bioactivity makes it a reliable tool for validating the significance of kinin fragments in disease models and drug discovery efforts targeting the KKS.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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