Calcitonin, eel CAS NO.57014-02-5

Eel Calcitonin is a potent hypocalcemic peptide hormone derived from eel origin, widely utilized in metabolic bone disease research and pharmaceutical development. This 32-amino acid peptide features a characteristic N-terminal disulfide bridge critical for its stability and receptor binding affinity, making it a valuable reference standard for studying calcium homeostasis. It is particularly suited for researchers investigating osteoclast inhibition, bone resorption pathways, and the development of therapeutic agents for conditions like osteoporosis and hypercalcemia.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Calcitonin, eel
CAS NO.	57014-02-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₆H₂₄₁N₄₃O₄₇S₂
Molecular Weight	3414.87g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in dilute acetic acid or 0.1% TFA in water; soluble in 1,2-dichloroethane/water mixture
Endotoxin	≤1 EU/mg (LAL test)
Biological Activity	Inhibits osteoclast-mediated bone resorption; reduces serum calcium levels
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Eel Calcitonin exerts its effects by binding to the calcitonin receptor (CTR) on osteoclasts and renal tubular cells, activating adenylate cyclase and increasing intracellular cAMP levels. This signaling cascade rapidly inhibits osteoclast-mediated bone resorption and promotes renal excretion of calcium and phosphate, thereby lowering serum calcium concentrations. Additionally, it demonstrates central and peripheral analgesic properties by modulating pain mediator release and increasing β-endorphin levels, providing dual benefits in managing bone pain associated with metabolic disorders.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research focused on postmenopausal and senile osteoporosis, Paget's disease of bone (osteitis deformans), and malignancy-associated hypercalcemia. It serves as a critical tool for evaluating bone density preservation, fracture risk reduction, and analgesic efficacy in animal models of bone metastasis or chronic skeletal pain. Researchers in endocrinology, orthopedics, and oncology utilize it to develop novel formulations and delivery systems for calcitonin-based therapies.

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3.CLINICAL EFFICACY OF PRODUCT

In clinical and experimental settings, Eel Calcitonin demonstrates significant efficacy in reducing bone turnover markers, increasing lumbar spine bone mineral density, and alleviating chronic bone pain. Studies show that sustained administration leads to statistically significant improvements in bone microarchitecture and biomechanical strength, with a favorable safety profile compared to other resorption inhibitors. Its rapid onset of action makes it particularly effective in acute hypercalcemia management and palliative care for cancer patients with skeletal complications.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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