C-Reactive Protein (CRP) (174-185) CAS NO.160369-86-8

C-Reactive Protein (CRP) (174-185) is a synthetic dodecapeptide fragment corresponding to the 174-185 amino acid sequence of human C-reactive protein, widely used as a potent immunomodulatory agent in preclinical research. This high-purity peptide is specifically designed for studying innate immune responses, particularly macrophage activation and neutrophil chemotaxis, making it an essential tool for researchers investigating atherosclerosis, sepsis, and cancer immunology. Its stability and bioactivity profile support applications in cell-based assays and animal models focused on acute-phase inflammatory pathways.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	C-Reactive Protein (CRP)
CAS NO.	160369-86-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₂H₉₃N₁₃O₁₆
Molecular Weight	1342.5g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, PBS, and DMSO (recommended concentration ≤10 mg/mL for stability)
Endotoxin	≤1 EU/mg (LAL test)
Biological Activity	Potent activator of macrophage phagocytosis and ROS production; enhances neutrophil chemotaxis and modulates FcγR signaling
Storage Conditions	Store at -20°C, protected from light; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a biological response modifier by interacting with Fc gamma receptors (FcγR) on phagocytic cells, primarily monocytes and macrophages, to enhance their cytotoxic potential. It stimulates the production of reactive oxygen species (ROS) and tissue factor activity, while also modulating neutrophil migration through L-selectin shedding and inhibition of chemotactic responses to IL-8. This dual action allows it to regulate leukocyte infiltration at inflammatory sites and amplify pathogen clearance mechanisms in experimental models of infection and tissue injury.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research applications related to cardiovascular inflammation, autoimmune disorders, and anti-tumor immunity. It serves as a critical reagent for calibrating immunoassays, validating macrophage-mediated cytotoxicity, and screening therapeutic candidates that target CRP signaling pathways. Researchers in immunology and pharmacology utilize it to model septic acute kidney injury, atherosclerotic plaque progression, and metastatic disease, providing insights into the role of acute-phase proteins in disease pathogenesis.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental settings, CRP (174-185) demonstrates significant efficacy in enhancing the tumoricidal activity of human monocytes against various cancer cell lines, confirming its role as an immunostimulatory agent. Preclinical data show its ability to improve outcomes in septic AKI models by promoting bacterial clearance and polarizing macrophages toward an anti-inflammatory M2 phenotype. While not for clinical use, its robust bioactivity in modulating cytokine release and oxidative burst responses establishes it as a reliable reference compound for drug discovery and mechanistic studies.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: CRP174185, #CReactiveProteinPeptide, #InflammationResearch, #MacrophageActivation, #Immunomodulator, #Atherosclerosis, #SepsisResearch, #ResearchPeptide

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