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CRF (6-33) (human, rat) CAS NO.120066-38-8

CRF (6-33) (human, rat) is a 28-amino acid neuropeptide fragment derived from the corticotropin-releasing factor, specifically designed as a high-affinity ligand for the CRF binding protein (CRF-BP). Unlike full-length CRF, this fragment does not activate CRF receptors, making it a selective tool for researchers studying the regulation of endogenous CRF bioavailability in stress physiology and metabolic disorders without inducing direct receptor-mediated stress responses.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	CRF (6-33) (human, rat)
CAS NO.	120066-38-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₁H₂₃₁N₄₁O₄₃S
Molecular Weight	3260.7g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in 1% acetic acid or dilute aqueous buffers (e.g., PBS, pH 5.0–7.0); insoluble in pure water
Endotoxin	≤1 EU/mg (LAL test, validated per USP <85>)
Biological Activity	Selective CRF Binding Protein (CRF-BP) ligand; displaces endogenous CRF without activating CRF1/CRF2 receptors
Storage Conditions	Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a competitive inhibitor of CRF-BP, binding to the binding protein with high affinity to displace endogenous CRF. By blocking the interaction between CRF and its binding protein, CRF (6-33) increases the concentration of free, biologically active CRF in the extracellular space, thereby indirectly amplifying CRF signaling pathways that modulate appetite and energy expenditure without engaging CRF1 or CRF2 receptors.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research into metabolic syndrome and stress-related eating disorders, particularly for investigating the role of CRF-BP in obesity models. It is utilized in studies requiring precise modulation of free CRF levels to assess feeding behavior, thermogenesis, and insulin sensitivity, providing a unique approach for neuroscientists and endocrinologists exploring non-receptor-mediated CRF effects.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental models, CRF (6-33) has demonstrated efficacy in reducing body weight and adiposity in diet-induced obese animals by enhancing endogenous CRF tone. It promotes negative energy balance through mechanisms such as suppressed food intake and elevated core body temperature, validating its utility as a reference standard for evaluating CRF-BP-targeted therapeutic strategies in metabolic disease research.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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